Design and synthesis of novel pyrrolo[2,3-a]carbazoles: 7-Chloro-2-oxo-3a-(2'-oxo-2',3'-dihydro-1'H-indol-3'-yl)-2,3,3a,4,5,10-hexahydro-pyrrolo[3,2-a]carbazole-1-carbonitrile as an efficient anticancer agent.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.056
Abstract: Highly efficient poly functionalized pyrrolo[3,2-a]carbazoles via ring contraction through rearrangement and intramolecular Michael addition reaction using one pot multicomponent reaction (MCR) is reported for the first time. Free radical scavenging and anticancer activities were determined… read more here.
Keywords: pyrrolo carbazoles; pyrrolo; chloro oxo; anticancer ... See more keywords
Synthesis of Methylene Bridged Bis-pyrrolo[3,2-c]carbazoles via an Unusual Vilsmeier–Haack Product of N-Ethylcarbazole
Sign Up to like & getrecommendations! Published in 2020 at "Polycyclic Aromatic Compounds"
DOI: 10.1080/10406638.2018.1458739
Abstract: ABSTRACT The unexpected result for the formylation of N-ethylcarbazole under the Vilsmeier–Haack conditions (POCl3/DMF) led to the synthesis of novel methylene bridged bis-pyrrolo[3,2-c]carbazoles via Hemetsberger indole synthesis was reported. A plausible mechanism for the formation… read more here.
Keywords: pyrrolo carbazoles; methylene bridged; bridged bis; vilsmeier haack ... See more keywords
Sequential Annulations to Interesting Novel Pyrrolo[3,2-c]carbazoles
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24203802
Abstract: Herein we report a significant, valuable extension of a recently implemented pyrrole benzannulation methodology that, employing versatile nitrodienes from our lab as useful C4 building blocks, led to indole derivatives characterized by unusual patterns of… read more here.
Keywords: methodology; pyrrolo carbazoles; novel pyrrolo; interesting novel ... See more keywords