Pyrrolo-isoquinoline and glycosylated pyrrolidine alkaloids from Nigella glandulifera and their anti-PTP1B activity
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DOI: 10.1016/j.phytol.2016.12.024
Abstract: Abstract Two new alkaloids, nigellisoquinomine ( 1 ) with a novel pyrrolo-isoquinoline skeleton, and nigellapyrrolidine ( 2 ) possessing a rare glycosylated pyrrolidine moiety, together with two known alkaloids, agrocybenine ( 3 ) and 4,6,6-trimethyl-3,4-epoxypiperidin-2-one… read more here.
Keywords: nigella glandulifera; pyrrolo isoquinoline; activity; glycosylated pyrrolidine ... See more keywords
I2-DMSO-Mediated N-H/α-C(sp3)-H Difunctionalization of Tetrahydroisoquinoline: Formal [2 + 2 + 1] Annulation for the Construction of Pyrrolo[2,1-a]isoquinoline Derivatives.
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DOI: 10.1021/acs.orglett.2c00813
Abstract: An I2-DMSO-mediated cascade reaction using methyl ketones and 1,2,3,4-tetrahydroisoquinolines (THIQs) as commercially available substrates has been developed for the construction of pyrrolo[2,1-a]isoquinoline derivatives. This metal-free process involves N-H/α-C(sp3)-H difunctionalization of THIQ. Two C-C bonds and… read more here.
Keywords: construction pyrrolo; dmso mediated; pyrrolo isoquinoline; sp3 difunctionalization ... See more keywords