Synthesis of pyrrolo[3,4-c]pyridine-1,3-diones (5-azaphthalimides) (microreview)
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DOI: 10.1007/s10593-020-02693-6
Abstract: The review summarizes the work devoted to the preparation of pyrrolo[3,4-c]pyridine-1,3-dione (5-azaphthalimide) derivatives over the last 10 years. Methods for the synthesis of pyrrolo[3,4-c]pyridine-1,3-dione derivatives are divided into three groups: annulation of the pyrrole moiety,… read more here.
Keywords: pyridine diones; pyrrolo pyridine; pyridine; synthesis pyrrolo ... See more keywords
Discovery of pyrrolo[2,3-b]pyridine (1,7-dideazapurine) nucleoside analogues as anti-Trypanosoma cruzi agents.
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DOI: 10.1021/acs.jmedchem.9b01275
Abstract: Trypanosoma cruzi is the causative pathogen of Chagas disease and the main culprit for cardiac-related mortality in Latin-America triggered by an infective agent. Uncapable of synthesizing purines de novo, this parasite depends on acquisition and… read more here.
Keywords: pyridine dideazapurine; pyrrolo pyridine; nucleoside analogues; trypanosoma cruzi ... See more keywords
Pyrrolo[3,2-c]pyridine derivatives with potential inhibitory effect against FMS kinase: in vitro biological studies
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DOI: 10.1080/14756366.2018.1491563
Abstract: Abstract A series of eighteen pyrrolo[3,2-c]pyridine derivatives were tested for inhibitory effect against FMS kinase. Compounds 1e and 1r were the most potent among all the other tested analogues (IC50 = 60 nM and 30 nM, respectively). They were… read more here.
Keywords: fms kinase; effect fms; pyrrolo pyridine; fms ... See more keywords