Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.
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DOI: 10.1021/acs.jmedchem.9b00136
Abstract: There are currently no approved drugs for the treatment of emerging viral infections, such as dengue and Ebola. Adaptor-associated kinase 1 (AAK1) is a cellular serine-threonine protein kinase that functions as a key regulator of… read more here.
Keywords: associated kinase; adaptor associated; structure activity; synthesis structure ... See more keywords
N-Heterocyclic Carbene-Catalyzed Atroposelective Synthesis of Pyrrolo[3,4-b]pyridines with Configurationally Stable C-N Axial Chirality.
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DOI: 10.1021/acs.orglett.2c01519
Abstract: The first atroposelective synthesis of pyrrolo[3,4-b]pyridines catalyzed by N-heterocyclic carbene has been achieved. A wide range of chiral atropisomers of pyrrolo[3,4-b]pyridines were obtained in high yields with excellent enantioselectivities (96-99% enantiomeric excess). The experimental results… read more here.
Keywords: pyrrolo pyridines; axial chirality; synthesis pyrrolo; atroposelective synthesis ... See more keywords
Ag(I)-Promoted, Diastereoselective Cyclo-isomerization of N-Alkynyl-7-azaindole-2-carbinols. Selective Synthesis of syn-1,2-Diarylpyrrolo[1,2-a]indol-3-ones and (Z)-8-Benzylideneoxazolo[3',4'':1,5]pyrrolo[2,3-b]pyridines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02179
Abstract: The design and development of an Ag(I)-promoted, highly diastereoselective cycloisomerization strategy for the synthesis of syn-1,2-diarylpyrrolo[1,2-a]indol-3-ones from N-alkynyl-indole-2-carbinols is reported. The H218O control experiment and identification of 18O-labeled product suggested the involvement of an external… read more here.
Keywords: benzylideneoxazolo pyrrolo; synthesis syn; syn diarylpyrrolo; pyrrolo pyridines ... See more keywords