Synthesis of 3H-Pyrrolo[2,3-c]quinoline by Sequential I2-Promoted Cyclization/Staudinger/Aza-Wittig/Dehydroaromatization Reaction
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DOI: 10.1055/s-0037-1610688
Abstract: A facile synthetic approach to access of 3H-pyrrolo[2,3-c]quinoline derivatives has been achieved by a sequential I2-promoted cyclization/Staudinger/aza-Wittig/dehydroaromatization reaction. The targeted products were received in moderate to good yields (62–81%). The broad substrate scope and easy… read more here.
Keywords: pyrrolo quinoline; sequential promoted; staudinger aza; cyclization staudinger ... See more keywords
Polymorphic modifications of a 1H-pyrrolo[3,2,1-ij]quinoline-5-carboxamide possessing strong diuretic properties.
Sign Up to like & getrecommendations! Published in 2018 at "Acta crystallographica. Section C, Structural chemistry"
DOI: 10.1107/s2053229618016352
Abstract: 6-Hydroxy-N-(4-methoxyphenyl)-4-oxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-5-carboxamide, C19H16N2O4, possesses strong diuretic properties and can be used as a new hypertension remedy. Two polymorphic modifications of this compound have been found, namely the triclinic polymorph (space group P-1), with one molecule in… read more here.
Keywords: diuretic properties; pyrrolo quinoline; polymorphic modifications; quinoline carboxamide ... See more keywords
Investigation of Antifungal Properties of Synthetic Dimethyl-4-Bromo-1-(Substituted Benzoyl) Pyrrolo[1,2-a] Quinoline-2,3-Dicarboxylates Analogues: Molecular Docking Studies and Conceptual DFT-Based Chemical Reactivity Descriptors and Pharmacokinetics Evaluation
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26092722
Abstract: Candida albicans, an opportunistic fungal pathogen, frequently colonizes immune-compromised patients and causes mild to severe systemic reactions. Only few antifungal drugs are currently in use for therapeutic treatment. However, evolution of a drug-resistant C. albicans… read more here.
Keywords: drug; dft based; pyrrolo quinoline; molecular docking ... See more keywords
Impact of the Substitution Pattern at the Basic Center and Geometry of the Amine Fragment on 5-HT6 and D3R Affinity in the 1H-Pyrrolo[3,2-c]quinoline Series
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DOI: 10.3390/molecules28031096
Abstract: Salt bridge (SB, double-charge-assisted hydrogen bonds) formation is one of the strongest molecular non-covalent interactions in biological systems, including ligand–receptor complexes. In the case of G-protein-coupled receptors, such an interaction is formed by the conserved… read more here.
Keywords: substitution pattern; pattern basic; geometry; pyrrolo quinoline ... See more keywords
Total synthesis of pyrrolo[2,3-c]quinoline alkaloid: trigonoine B
Sign Up to like & getrecommendations! Published in 2021 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.17.62
Abstract: The first total synthesis of the pyrrolo[2,3-c]quinoline alkaloid trigonoine B (1) was accomplished via a six-step sequence involving the construction of an N-substituted 4-aminopyrrolo[2,3-c]quinoline framework via electrocyclization of 2-(pyrrol-3-yl)benzene containing a carbodiimide moiety as a… read more here.
Keywords: synthesis pyrrolo; pyrrolo quinoline; quinoline alkaloid; total synthesis ... See more keywords