Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors.
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DOI: 10.1016/j.bioorg.2022.105706
Abstract: A series of 17 indolo/pyrroloazepinone-oxindole conjugates was synthesized and evaluated for their antiproliferative activity against a panel of selected human cancer cell lines including A549 (lung cancer), HCT116 (colon cancer), MCF7 (breast cancer), and SK-MEL-28… read more here.
Keywords: cancer; dna; synthesis indolo; pyrroloazepinone oxindoles ... See more keywords