Aspcandine: A Pyrrolobenzazepine Alkaloid Synthesized by a Fungal Nonribosomal Peptide Synthetase-Polyketide Synthase Hybrid.
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DOI: 10.1021/acs.orglett.2c01918
Abstract: Characterization of an orphan biosynthetic gene cluster found in the fungus Aspergillus candidus CBS 102.13 resulted in the discovery of a pyrrolobenzazepine alkaloid, aspcandine (1). The unique molecular scaffold of 1 is synthesized by the… read more here.
Keywords: peptide synthetase; pyrrolobenzazepine alkaloid; synthetase polyketide; polyketide synthase ... See more keywords