Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1,4]diazepine scaffold
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DOI: 10.1016/j.tet.2018.09.025
Abstract: Abstract Using a Tube-in-Tube device based on the amorphous Teflon AF-2400 fluoropolymer, a series of nitroarenes was hydrogenated to afford the corresponding aniline compounds. The system was then applied to the construction of a pyrrolobenzo[1,4]diazapene… read more here.
Keywords: gas liquid; hydrogenation; liquid flow; flow hydrogenation ... See more keywords