Development of small-molecule BRD4 degraders based on pyrrolopyridone derivative.
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DOI: 10.1016/j.bioorg.2020.103817
Abstract: Bromodomain-containing protein 4 (BRD4) plays a crucial role in the epigenetic regulation of gene transcription and some BRD4 inhibitors have been advanced to clinical trials. Nevertheless, the clinical application of BRD4 inhibitors could be limited… read more here.
Keywords: pyrrolopyridone derivative; brd4 degraders; small molecule; development small ... See more keywords