Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases.
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DOI: 10.1016/j.ejmech.2019.112021
Abstract: A series of novel sulfonamide derivatives bearing pyrrole and pyrrolopyrimidine scaffolds were synthesized and screened as carbonic anhydrase inhibitors. The inhibition activity of the synthesized compounds was evaluated against the cytosolic human carbonic anhydrase isoforms… read more here.
Keywords: cytotoxic agents; sulfonamides act; pyrrolopyrimidine; pyrrolopyrimidine sulfonamides ... See more keywords