Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis.
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DOI: 10.1021/acsinfecdis.0c00803
Abstract: Bumped kinase inhibitors (BKIs) that target Cryptosporidium parvum calcium-dependent protein kinase 1 have been well established as potential drug candidates against cryptosporidiosis. Recently, BKI-1649, with a 7H-pyrrolo[2,3-d]pyrimidin-4-amine, or "pyrrolopyrimidine", central scaffold, has shown improved efficacy… read more here.
Keywords: kinase inhibitors; bumped kinase; pyrrolopyrimidine bumped; inhibitors treatment ... See more keywords