Erythrocyte ATP, a possible therapeutic approach for sickle cell disease
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25419
Abstract: This letter presents some suggestions of possible therapies for sickle cell disease that are based on interpretations of presumed effects of different substrates that alter the cellular levels of ATP. A prevailing idea is that… read more here.
Keywords: atp; pyruvate; cell disease; sickle ... See more keywords
Enhanced pyruvate production in Candida glabrata by carrier engineering
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26477
Abstract: Pyruvate is an important organic acid that plays a key role in the central metabolic pathway. Manipulating transporters is an efficient strategy to enhance production of target organic acids and a means to understand the… read more here.
Keywords: pyruvate production; production; pyruvate; intracellular pyruvate ... See more keywords
Metabolic Tumor Imaging with Rapidly Signal‐Enhanced 1‐13C‐Pyruvate‐d3
Sign Up to like & getrecommendations! Published in 2022 at "Chemphyschem"
DOI: 10.1002/cphc.202200615
Abstract: Abstract The metabolism of malignant cells differs significantly from that of healthy cells and thus, it is possible to perform metabolic imaging to reveal not only the exact location of a tumor, but also intratumoral… read more here.
Keywords: signal enhanced; pyruvate; metabolic tumor; 13c pyruvate ... See more keywords
Escherichia coli aceE variants coding pyruvate dehydrogenase improve the generation of pyruvate‐derived acetoin
Sign Up to like & getrecommendations! Published in 2023 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.202200054
Abstract: Several chromosomally expressed AceE variants were constructed in Escherichia coli ΔldhA ΔpoxB ΔppsA and compared using glucose as the sole carbon source. These variants were examined in shake flask cultures for growth rate, pyruvate accumulation,… read more here.
Keywords: coli acee; escherichia coli; acee variants; pyruvate derived ... See more keywords
Age-associated change in pyruvate metabolism investigated with hyperpolarized 13 C-MRI of the human brain.
Sign Up to like & getrecommendations! Published in 2023 at "Human brain mapping"
DOI: 10.1002/hbm.26329
Abstract: In this study, hyperpolarized 13 C MRI (HP-13 C MRI) was used to investigate changes in the uptake and metabolism of pyruvate with age. Hyperpolarized 13 C-pyruvate was administered to healthy aging individuals (N = 35, ages… read more here.
Keywords: change; brain; age; human brain ... See more keywords
Modulating mitochondrial pyruvate carrier: A promising therapeutic target in Parkinson's disease
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.26962
Abstract: Mitochondrial pyruvate carrier (MPC) is a key protein complex in the control of cellular metabolism. Recent evidence suggests that a group of antidiabetic compounds, called thiazolidinedione (TZD) insulin sensitizers, slow the entry of pyruvate into… read more here.
Keywords: msdc 0160; pyruvate; target; pyruvate carrier ... See more keywords
Pyruvate cellular uptake and enzymatic conversion probed by dissolution DNP‐NMR: the impact of overexpressed membrane transporters
Sign Up to like & getrecommendations! Published in 2017 at "Magnetic Resonance in Chemistry"
DOI: 10.1002/mrc.4553
Abstract: Pyruvate membrane crossing and its lactate dehydrogenase‐mediated conversion to lactate in cells featuring different levels of expression of membrane monocarboxylate transporters (MCT4) were probed by dissolution dynamic nuclear polarization‐enhanced NMR. Hyperpolarized 13C‐1‐labeled pyruvate was transferred… read more here.
Keywords: pyruvate; conversion; pyruvate cellular; probed dissolution ... See more keywords
Improving multiparametric MR‐transrectal ultrasound guided fusion prostate biopsies with hyperpolarized 13C pyruvate metabolic imaging: A technical development study
Sign Up to like & getrecommendations! Published in 2022 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.29399
Abstract: To develop techniques and establish a workflow using hyperpolarized carbon‐13 (13C) MRI and the pyruvate‐to‐lactate conversion rate (kPL) biomarker to guide MR‐transrectal ultrasound fusion prostate biopsies. read more here.
Keywords: transrectal ultrasound; pyruvate; prostate biopsies; fusion prostate ... See more keywords
Increasing Infusion Times of Hyperpolarized [1-13C]Pyruvate in a Mouse Brain Maintain Lactate Generation and Approach Pseudo-Steady State Metabolism.
Sign Up to like & getrecommendations! Published in 2025 at "Magnetic resonance in medicine"
DOI: 10.1002/mrm.70175
Abstract: PURPOSE To investigate whether varying delivery times of hyperpolarized [1-13C]pyruvate, enabled by the increased apparent T1 dissolved in deuterium oxide (D2O), affects the observed kinetics of glycolytic brain metabolism in vivo. METHODS Eighteen healthy mice… read more here.
Keywords: hyperpolarized 13c; times hyperpolarized; metabolism; 13c pyruvate ... See more keywords
Brain metabolism under different anesthetic conditions using hyperpolarized [1‐13C]pyruvate and [2‐13C]pyruvate
Sign Up to like & getrecommendations! Published in 2018 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4012
Abstract: Carbon‐13 NMR spectroscopy (13C MRS) offers the unique capability to measure brain metabolic rates in vivo. Hyperpolarized 13C reduces the time required to assess brain metabolism from hours to minutes when compared with conventional 13C… read more here.
Keywords: anesthetic conditions; pyruvate; metabolism; 13c pyruvate ... See more keywords
Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1‐13C]pyruvate
Sign Up to like & getrecommendations! Published in 2020 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4250
Abstract: Hyperpolarised [1‐13C]pyruvate MRI has shown promise in monitoring therapeutic efficacy in a number of cancers including glioma. In this study, we assessed the pyruvate response to the lentiviral suicide gene therapy of herpes simplex virus‐1… read more here.
Keywords: glioma; pyruvate; gene therapy; 13c pyruvate ... See more keywords