Semi-rational evolution of pyruvate carboxylase from Rhizopus oryzae for elevated fumaric acid synthesis in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2021.108238
Abstract: Abstract Dicarboxylic acids are widely used in food, pharmaceutical, and chemical industries. Pyruvate carboxylase (PYC) plays a pivotal role in the production of dicarboxylic acids in microbial fermentation process. Our previous work showed that heterologous… read more here.
Keywords: fumaric acid; rhizopus oryzae; synthesis; pyruvate carboxylase ... See more keywords
Inhibition of pyruvate carboxylase by 1α,25-dihydroxyvitamin D promotes oxidative stress in early breast cancer progression.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.09.045
Abstract: Maintaining reductive-oxidative (redox) balance is an essential feature in breast cancer cell survival, with cellular metabolism playing an integral role in maintaining redox balance through its supply of reduced NADPH. In the present studies, the… read more here.
Keywords: cancer; oxidative stress; pyruvate carboxylase; breast cancer ... See more keywords
Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.05.013
Abstract: Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with… read more here.
Keywords: wields double; pyruvate carboxylase; carboxylase; carboxylase wields ... See more keywords
Long noncoding RNA OVAAL enhances nucleotide synthesis through pyruvate carboxylase to promote 5‐fluorouracil resistance in gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15453
Abstract: 5‐Fluorouracil (5‐FU) is widely used in gastric cancer treatment, yet 5‐FU resistance remains an important clinical challenge. We established a model based on five long noncoding RNAs (lncRNA) to effectively assess the prognosis of gastric… read more here.
Keywords: long noncoding; gastric cancer; pyruvate carboxylase; resistance gastric ... See more keywords
Control of biotin biosynthesis in mycobacteria by a pyruvate carboxylase dependent metabolic signal
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Microbiology"
DOI: 10.1111/mmi.13865
Abstract: Biotin is an essential cofactor utilized by all domains of life, but only synthesized by bacteria, fungi and plants, making biotin biosynthesis a target for antimicrobial development. To understand biotin biosynthesis in mycobacteria, we executed… read more here.
Keywords: biosynthesis mycobacteria; biotin; biotin biosynthesis; pyruvate carboxylase ... See more keywords
Sustained Control of Pyruvate Carboxylase by the Essential Second Messenger Cyclic di-AMP in Bacillus subtilis
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03602-21
Abstract: If bacteria experience a starvation for potassium, by far the most abundant metal ion in every living cell, they have to activate high-affinity potassium transporters, switch off growth activities such as translation and transcription of… read more here.
Keywords: cyclic amp; bacillus subtilis; starvation; carboxylase ... See more keywords
Abstract 656: Suppression of pyruvate carboxylase drives tumor microenvironment immunosuppression
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-656
Abstract: Metabolic reprogramming and immune evasion are established hallmarks of the tumor microenvironment (TME). Tumor metabolic dysregulation is a key mediator of tumor immune evasion. High levels of lactate produced by the tumor potently suppress antitumor… read more here.
Keywords: pyruvate carboxylase; tumor microenvironment; tumor; suppression ... See more keywords
Challenges in the management of an ignored cause of hyperammonemic encephalopathy: pyruvate carboxylase deficiency
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2019-0307
Abstract: Abstract Pyruvate carboxylase (PC) deficiency is a rare autosomal recessive disease and provides clinics in three essential phenotypes. Type B PC deficiency is characterized by lactic acidosis and hyperammonemia. We report a Turkish patient who… read more here.
Keywords: management; deficiency; carboxylase deficiency; pyruvate carboxylase ... See more keywords
Pyruvate carboxylase deficiency type C as a differential diagnosis of diabetic ketoacidosis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2020-0646
Abstract: Abstract Objectives Type C pyruvate carboxylase (PC) deficiency is extremely rare, and has been described in only a few patients in literature to date. Herein, we present the case of a four-year-old patient admitted with… read more here.
Keywords: deficiency; pyruvate carboxylase; carboxylase deficiency; diabetic ketoacidosis ... See more keywords
Elevated Brain Glutamate Levels in Bipolar Disorder and Pyruvate Carboxylase-Mediated Anaplerosis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2021.640977
Abstract: In vivo 1H magnetic resonance spectroscopy studies have found elevated brain glutamate or glutamate + glutamine levels in bipolar disorder with surprisingly high reproducibility. We propose that the elevated glutamate levels in bipolar disorder can… read more here.
Keywords: carboxylase mediated; disorder; pyruvate carboxylase; levels bipolar ... See more keywords
Discrimination of Bacillus subtilis from Other Bacillus Species Using Specific Oligonucleotide Primers for the Pyruvate Carboxylase and Shikimate Dehydrogenase Genes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Microbiology and Biotechnology"
DOI: 10.4014/jmb.2205.05014
Abstract: Bacillus subtilis is a useful bacterium in the food industry with applications as a starter strain for fermented food and as a probiotic. However, it is difficult to discriminate B. subtilis from other Bacillus species… read more here.
Keywords: bacillus subtilis; bacillus species; shikimate dehydrogenase; discrimination ... See more keywords