Semi-rational evolution of pyruvate carboxylase from Rhizopus oryzae for elevated fumaric acid synthesis in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2021.108238
Abstract: Abstract Dicarboxylic acids are widely used in food, pharmaceutical, and chemical industries. Pyruvate carboxylase (PYC) plays a pivotal role in the production of dicarboxylic acids in microbial fermentation process. Our previous work showed that heterologous… read more here.
Keywords: fumaric acid; rhizopus oryzae; synthesis; pyruvate carboxylase ... See more keywords
Inhibition of pyruvate carboxylase by 1α,25-dihydroxyvitamin D promotes oxidative stress in early breast cancer progression.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.09.045
Abstract: Maintaining reductive-oxidative (redox) balance is an essential feature in breast cancer cell survival, with cellular metabolism playing an integral role in maintaining redox balance through its supply of reduced NADPH. In the present studies, the… read more here.
Keywords: cancer; oxidative stress; pyruvate carboxylase; breast cancer ... See more keywords
Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.05.013
Abstract: Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with… read more here.
Keywords: wields double; pyruvate carboxylase; carboxylase; carboxylase wields ... See more keywords
Synthesis and Evaluation of 1,3-Disubstituted Imidazolidine-2,4,5-triones as Inhibitors of Pyruvate Carboxylase.
Sign Up to like & getrecommendations! Published in 2024 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.4c00183
Abstract: Substituted imidazolidinetriones (IZTs) have been identified as potent inhibitors of pyruvate carboxylase (PC) through an in silico screening approach. Alkyl 2-(2,4,5-trioxo-3-substituted imidazolidin-1-yl)acetates (6i-6r) are the most potent of the series, with IC50 values between 3… read more here.
Keywords: imidazolidine triones; pyruvate carboxylase; inhibitors pyruvate; synthesis evaluation ... See more keywords
Long noncoding RNA OVAAL enhances nucleotide synthesis through pyruvate carboxylase to promote 5‐fluorouracil resistance in gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15453
Abstract: 5‐Fluorouracil (5‐FU) is widely used in gastric cancer treatment, yet 5‐FU resistance remains an important clinical challenge. We established a model based on five long noncoding RNAs (lncRNA) to effectively assess the prognosis of gastric… read more here.
Keywords: long noncoding; gastric cancer; pyruvate carboxylase; resistance gastric ... See more keywords
Control of biotin biosynthesis in mycobacteria by a pyruvate carboxylase dependent metabolic signal
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Microbiology"
DOI: 10.1111/mmi.13865
Abstract: Biotin is an essential cofactor utilized by all domains of life, but only synthesized by bacteria, fungi and plants, making biotin biosynthesis a target for antimicrobial development. To understand biotin biosynthesis in mycobacteria, we executed… read more here.
Keywords: biosynthesis mycobacteria; biotin; biotin biosynthesis; pyruvate carboxylase ... See more keywords
Sustained Control of Pyruvate Carboxylase by the Essential Second Messenger Cyclic di-AMP in Bacillus subtilis
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03602-21
Abstract: If bacteria experience a starvation for potassium, by far the most abundant metal ion in every living cell, they have to activate high-affinity potassium transporters, switch off growth activities such as translation and transcription of… read more here.
Keywords: cyclic amp; bacillus subtilis; starvation; carboxylase ... See more keywords
Abstract 656: Suppression of pyruvate carboxylase drives tumor microenvironment immunosuppression
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-656
Abstract: Metabolic reprogramming and immune evasion are established hallmarks of the tumor microenvironment (TME). Tumor metabolic dysregulation is a key mediator of tumor immune evasion. High levels of lactate produced by the tumor potently suppress antitumor… read more here.
Keywords: pyruvate carboxylase; tumor microenvironment; tumor; suppression ... See more keywords
Abstract 781: Impact of vitamin D and pyruvate carboxylase on hypoxia inducible lipid droplet associated (HILPDA) protein in metastatic breast cancer cells
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-781
Abstract: Metastatic breast cancer, a critical health issue for women globally, is closely linked to aberrant lipid metabolism. One feature of this dysregulated metabolism is the increase in lipid storage in the form of cytoplasmic lipid… read more here.
Keywords: cancer; breast cancer; cancer cells; pyruvate carboxylase ... See more keywords
Abstract 4147720: Dual Inhibition of Glutaminolysis and Pyruvate Carboxylase Attenuates Pulmonary Arterial Hypertension
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4147720
Abstract: Introduction: Pulmonary arterial hypertension (PAH) is a serious condition that impacts the lung vasculature and has diverse underlying factors. Previous research has shown that mitochondrial dysfunction (MD) significantly contributes to PAH; however, the mechanisms remain… read more here.
Keywords: pah; pyruvate carboxylase; glutaminolysis; anaplerosis ... See more keywords
Challenges in the management of an ignored cause of hyperammonemic encephalopathy: pyruvate carboxylase deficiency
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2019-0307
Abstract: Abstract Pyruvate carboxylase (PC) deficiency is a rare autosomal recessive disease and provides clinics in three essential phenotypes. Type B PC deficiency is characterized by lactic acidosis and hyperammonemia. We report a Turkish patient who… read more here.
Keywords: management; deficiency; carboxylase deficiency; pyruvate carboxylase ... See more keywords