Modulating mitochondrial pyruvate carrier: A promising therapeutic target in Parkinson's disease
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.26962
Abstract: Mitochondrial pyruvate carrier (MPC) is a key protein complex in the control of cellular metabolism. Recent evidence suggests that a group of antidiabetic compounds, called thiazolidinedione (TZD) insulin sensitizers, slow the entry of pyruvate into… read more here.
Keywords: msdc 0160; pyruvate; target; pyruvate carrier ... See more keywords
Mitochondrial pyruvate carrier as a key regulator of fever and neuroinflammation
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.11.031
Abstract: The mitochondrial pyruvate carrier (MPC) is an inner-membrane transporter that facilitates pyruvate uptake from the cytoplasm into mitochondria. We previously reported that MPC1 protein levels increase in the hypothalamus of animals during fever induced by… read more here.
Keywords: pyruvate; fever; neuroinflammation; pyruvate carrier ... See more keywords
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.11.002
Abstract: Although metabolic adaptations have been demonstrated to be essential for tumor cell proliferation, the metabolic underpinnings of tumor initiation are poorly understood. We found that the earliest stages of colorectal cancer (CRC) initiation are marked… read more here.
Keywords: initiation; tumor initiation; pyruvate carrier; mitochondrial pyruvate ... See more keywords
Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2020.01.024
Abstract: Summary In mitochondria, the carrier translocase (TIM22 complex) facilitates membrane insertion of multi-spanning proteins with internal targeting signals into the inner membrane [1, 2, 3]. Tom70, a subunit of TOM complex, represents the major receptor… read more here.
Keywords: tim22 complex; substrate spectrum; tim22; carrier ... See more keywords
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02093
Abstract: A new series of analogues or derivatives of the previously reported PPARα/γ dual agonist LT175 allowed the identification of ligand 10, which was able to potently activate both PPARα and -γ subtypes as full and… read more here.
Keywords: pyruvate carrier; inhibition; mitochondrial pyruvate; new antidiabetic ... See more keywords
Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000279
Abstract: BACKGROUND AND AIMS NAFLD has become a major metabolic disease worldwide. A few studies have reported the potential relationship between mitochondrial pyruvate carrier (MPC1) and inflammation, fibrosis, and insulin sensitivity in obese or NASH mouse… read more here.
Keywords: acid synthase; pyruvate carrier; lactylation; mitochondrial pyruvate ... See more keywords
Mitochondrial pyruvate carrier 1 mediates abscisic acid-regulated stomatal closure and the drought response by affecting cellular pyruvate content in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2017 at "BMC Plant Biology"
DOI: 10.1186/s12870-017-1175-3
Abstract: BackgroundStomata are micropores surrounded by pairs of guard cells, and their opening is finely controlled to balance water vapor loss as transpiration and CO2 absorption for photosynthesis. The regulatory signaling network for stomatal movement is… read more here.
Keywords: drought; pyruvate; stomatal closure; pyruvate carrier ... See more keywords
Identification of Mitochondrial Pyruvate Carrier Modulators to Treat Diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-1770-p
Abstract: Recent work conducted in knockout mouse models or using small molecule modulators of the mitochondrial pyruvate carrier (MPC) have suggested that targeting this protein complex may have efficacy for treating diabetes as insulin sensitizers. To… read more here.
Keywords: mpc; pyruvate; zaprinast; pyruvate carrier ... See more keywords
The Hepatic Mitochondrial Pyruvate Carrier as a Regulator of Systemic Metabolism and a Therapeutic Target for Treating Metabolic Disease
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13020261
Abstract: Pyruvate sits at an important metabolic crossroads of intermediary metabolism. As a product of glycolysis in the cytosol, it must be transported into the mitochondrial matrix for the energy stored in this nutrient to be… read more here.
Keywords: metabolism; mitochondrial pyruvate; pyruvate carrier; pyruvate ... See more keywords
NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate Carrier Complexes
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13050719
Abstract: The mitochondrial pyruvate carrier (Mpc) plays an indispensable role in the transport of pyruvates across the mitochondrial inner membrane. Despite the two distinct homologous proteins, Mpc1 and Mpc2, were identified in 2012, there are still… read more here.
Keywords: pyruvate carrier; mpc1 mpc2; mitochondrial pyruvate; patch clamp ... See more keywords
Identification of Novel Mitochondrial Pyruvate Carrier Inhibitors by Homology Modeling and Pharmacophore-Based Virtual Screening
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020365
Abstract: The mitochondrial pyruvate carrier (MPC) is an inner-mitochondrial membrane protein complex that has emerged as a drug target for treating a variety of human conditions. A heterodimer of two proteins, MPC1 and MPC2, comprises the… read more here.
Keywords: pyruvate; pyruvate carrier; homology modeling; mpc ... See more keywords