Cover Feature: Regulation of pyruvate dehydrogenase complex related to lactate switch in CHO cells.
Sign Up to like & getrecommendations! Published in 2021 at "Engineering in life sciences"
DOI: 10.1002/elsc.202170027
Abstract: DOI: 10.1002/elsc.202000037 The cover feature visualizes our recent article about the investigation of the regulation of the Pyruvate Dehydrogenase Complex (PDC) during the lactate switch in batch cultures of Chinese Hamster Ovary cells. The relevance… read more here.
Keywords: lactate switch; dehydrogenase complex; regulation pyruvate; cover feature ... See more keywords
Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.31812
Abstract: During malignant progression cancer cells undergo a series of changes, which promote their survival, invasiveness and metastatic process. One of them is a change in glucose metabolism. Unlike normal cells, which mostly rely on the… read more here.
Keywords: microenvironmental control; dehydrogenase; glucose metabolism; cancer ... See more keywords
Pyruvate dehydrogenase kinase 4 promotes ubiquitin–proteasome system‐dependent muscle atrophy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13100
Abstract: Muscle atrophy, leading to muscular dysfunction and weakness, is an adverse outcome of sustained period of glucocorticoids usage. However, the molecular mechanism underlying this detrimental condition is currently unclear. Pyruvate dehydrogenase kinase 4 (PDK4), a… read more here.
Keywords: muscle atrophy; pyruvate dehydrogenase; muscle; dehydrogenase kinase ... See more keywords
Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a1119-236r
Abstract: The pyruvate dehydrogenase complex (PDC)/pyruvate dehydrogenase kinase (PDK) axis directs the universal survival principles of immune resistance and tolerance in monocytes by controlling anabolic and catabolic energetics. Immune resistance shifts to immune tolerance during inflammatory… read more here.
Keywords: tca cycle; cycle; dehydrogenase complex; pyruvate dehydrogenase ... See more keywords
Sepsis, pyruvate, and mitochondria energy supply chain shortage
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3mr0322-692rr
Abstract: Balancing high energy‐consuming danger resistance and low energy supply of disease tolerance is a universal survival principle that often fails during sepsis. Our research supports the concept that sepsis phosphorylates and deactivates mitochondrial pyruvate dehydrogenase… read more here.
Keywords: sepsis; energy supply; energy; pyruvate dehydrogenase ... See more keywords
Pyruvate dehydrogenase subunit β of Lactobacillus plantarum is a collagen adhesin involved in biofilm formation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Basic Microbiology"
DOI: 10.1002/jobm.201600575
Abstract: Multi‐functional surface proteins have been observed in a variety of pathogenic bacteria, where they mediate host cell adhesion and invasion, as well as in commensal bacterial species, were they mediate positive interaction with the host.… read more here.
Keywords: collagen; cni; lactobacillus plantarum; pyruvate dehydrogenase ... See more keywords
Pyruvate dehydrogenase deficiency disease detected by the enzyme activity of peripheral leukocytes
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1728
Abstract: Pyruvate dehydrogenase complex (PDHC) deficiency is a common neurodegenerative disease associated with abnormal mitochondrial energy metabolism. The diagnosis of PDHC is difficult because of the lack of a rapid, accurate, and cost‐effective clinical diagnostic method. read more here.
Keywords: disease detected; dehydrogenase deficiency; deficiency; deficiency disease ... See more keywords
Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS
Sign Up to like & getrecommendations! Published in 2018 at "Nmr in Biomedicine"
DOI: 10.1002/nbm.3992
Abstract: Hyperpolarized [1‐13C] pyruvate MRS can measure cardiac pyruvate dehydrogenase (PDH) flux in vivo through 13C‐label incorporation into bicarbonate. Using this technology, substrate availability as well as pathology have been shown to modulate PDH flux. Clinical… read more here.
Keywords: cardiac pyruvate; flux; pdh flux; pyruvate dehydrogenase ... See more keywords
X-linked pyruvate dehydrogenase complex deficiency due to a novel PDHA1 variant associated with structural brain abnormalities in a fetus.
Sign Up to like & getrecommendations! Published in 2023 at "Prenatal diagnosis"
DOI: 10.1002/pd.6349
Abstract: We report a case of pyruvate dehydrogenase E1 alpha subunit deficiency associated with a novel hemizygous PDHA1 variant presenting prenatally as multiple structural brain abnormalities in a male fetus. A healthy Finnish couple was initially… read more here.
Keywords: structural brain; pyruvate dehydrogenase; pdha1 variant; brain abnormalities ... See more keywords
Restoration of fitness lost due to dysregulation of the pyruvate dehydrogenase complex is triggered by ribosomal binding site modifications
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108961
Abstract: SUMMARY Pyruvate dehydrogenase complex (PDC) functions as the main determinant of the respiro-fermentative balance because it converts pyruvate to acetyl-coenzyme A (CoA), which then enters the TCA (tricarboxylic acid cycle). PDC is repressed by the… read more here.
Keywords: pdc; dehydrogenase complex; evolved strains; pyruvate dehydrogenase ... See more keywords
High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.12.051
Abstract: Overexpression of pyruvate dehydrogenase kinases (PDKs) has been widely noticed in a variety of human solid tumors, which could be regarded as an attractive therapeutic target for cancer therapy. In this paper, we present an… read more here.
Keywords: dehydrogenase; dehydrogenase kinases; cancer; cell ... See more keywords