Efficacy and safety of half‐dose desmopressin for bleeding prophylaxis in bleeding disorder patients undergoing predominantly low to moderate risk invasive procedures
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Hematology"
DOI: 10.1002/ajh.25928
Abstract: of disease in pyruvate kinase deficiency and their management. Haematologica. 2020:haematol.2019.240846. https://doi.org/10.3324/ haematol.2019.240846. 5. Necheles TF, Finkel HE, Sheehan RG, Allen DM. Red cell pyruvate kinase deficiency. The effect of splenectomy. Arch Intern Med. 1966;… read more here.
Keywords: pyruvate kinase; half dose; efficacy safety; desmopressin bleeding ... See more keywords
Pyruvate kinase M2 (PKM2) improve symptoms of post‐ischemic stroke depression by activating VEGF to mediate the MAPK/ERK pathway
Sign Up to like & getrecommendations! Published in 2021 at "Brain and Behavior"
DOI: 10.1002/brb3.2450
Abstract: To evaluate and identify the effects and explore the mechanisms of pyruvate kinase M2 (PKM2) on stroke‐induced post stroke depression (PSD). read more here.
Keywords: kinase pkm2; stroke depression; pyruvate kinase;
Serendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200339
Abstract: Enzymes are effective biological catalysts that accelerate almost all metabolic reactions in living organisms. Synthetic modulators of enzymes are useful tools for the study of enzymatic reactions and can provide starting points for the design… read more here.
Keywords: liver pyruvate; covalent; pyruvate kinase;
Safety, Pharmacokinetics, and Pharmacodynamics of Etavopivat (FT-4202), an Allosteric Activator of Pyruvate Kinase-R, in Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, First-in-Human Phase 1 Trial.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1058
Abstract: Etavopivat (FT-4202) is an orally administered, small-molecule allosteric activator of erythrocyte pyruvate kinase-R (PKR) in clinical development for the treatment of sickle cell disease and other hemoglobin disorders. This randomized, placebo-controlled, double-blind, first-in-human combination single-ascending… read more here.
Keywords: safety; placebo; randomized placebo; allosteric activator ... See more keywords
Odd one out? Functional tuning of Zymomonas mobilis pyruvate kinase is narrower than its allosteric, human counterpart
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4336
Abstract: Various protein properties are often illuminated using sequence comparisons of protein homologs. For example, in analyses of the pyruvate kinase multiple sequence alignment, the set of positions that changed during speciation (“phylogenetic” positions) were enriched… read more here.
Keywords: zymomonas mobilis; pyruvate kinase; zmpyk; rheostat positions ... See more keywords
Nutritional regulation of pyruvate kinase and phosphoenolpyruvate carboxykinase at the enzymatic and molecular levels in cobia Rachycentron canadum
Sign Up to like & getrecommendations! Published in 2019 at "Fish Physiology and Biochemistry"
DOI: 10.1007/s10695-019-00612-x
Abstract: Despite being a carnivorous fish species, cobia (Rachycentron canadum) can utilize high levels of dietary carbohydrate (up to 360 g kg−1). By contrast, rainbow trout (also carnivorous) cannot, due to the absence of molecular induction of glycolytic… read more here.
Keywords: pyruvate kinase; cobia rachycentron; cho ratio; rachycentron canadum ... See more keywords
Purification and Characterization of Prolyl Hydroxylase 3/Pyruvate Kinase Isoform 2 Protein Complex
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biotechnology"
DOI: 10.1007/s12033-019-00228-9
Abstract: The prolyl hydroxylase 3 (PHD3) protein is less abundant in normal oxygen conditions (normoxia) but increases under deficient oxygen condition (hypoxia). Since cancerous cells often thrive in hypoxic conditions and predominantly express the Pyruvate kinase… read more here.
Keywords: protein; pyruvate kinase; phd3 pkm2; pkm2 ... See more keywords
Posttranslational modification of pyruvate kinase type M2 (PKM2): novel regulation of its biological roles to be further discovered.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of physiology and biochemistry"
DOI: 10.1007/s13105-021-00813-0
Abstract: PKM2, pyruvate kinase type M2, has been shown to play a key role in aerobic glycolysis and to regulate the malignant behaviors of cancer cells. Recently, PKM2 has been revealed to hold dual metabolic and… read more here.
Keywords: pyruvate kinase; kinase; pkm2; posttranslational modification ... See more keywords
Pyruvate kinase from Geobacillus stearothermophilus displays an unusual preference for Mn2+ in a cycling reaction.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2019.02.005
Abstract: Previously, we developed a kinase cycling method using creatine kinase and pyruvate kinase (RMPK) both from rabbit muscle in the presence of an excess amount of ATP and IDP for the quantitative determination of substrate.… read more here.
Keywords: pyruvate kinase; mn2; geobacillus stearothermophilus; reaction ... See more keywords
Pyruvate kinase deficiency: novel mutations and a better understanding of the genotype-to-phenotype correlation in Brazilian patients☆
Sign Up to like & getrecommendations! Published in 2018 at "Hematology, Transfusion and Cell Therapy"
DOI: 10.1016/j.bjhh.2017.08.009
Abstract: Over the past few years, the inherited disorders of erythrocyte metabolism have been the object of intensive research resulting in a better understanding of their molecular basis.1 Pyruvate kinase (PK) deficiency is the most common… read more here.
Keywords: deficiency novel; pyruvate kinase; better understanding; kinase deficiency ... See more keywords
Chokepoints in Mechanical Coupling Associated with Allosteric Proteins: The Pyruvate Kinase Example.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.03.026
Abstract: Although the critical role of allostery in controlling enzymatic processes is well appreciated, there is a current dearth in our understanding of its underlying mechanisms, including communication between binding sites. One potential key aspect of… read more here.
Keywords: distant parts; pyruvate kinase; parts protein; coupling ... See more keywords