Genome‐Wide CRISPR/Cas9 Library Screening Revealed Dietary Restriction of Glutamine in Combination with Inhibition of Pyruvate Metabolism as Effective Liver Cancer Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202104
Abstract: Hepatocellular carcinoma (HCC) is the second most lethal cancer worldwide. Glutamine is an essential, extracellular nutrient which supports HCC growth. Dietary glutamine deficiency may be a potential therapeutic approach for HCC. HCC cells overcome metabolic… read more here.
Keywords: glutamine; treatment; hcc; pyruvate metabolism ... See more keywords
The number of glomeruli and pyruvate metabolism is not strongly coupled in the healthy rat kidney.
Sign Up to like & getrecommendations! Published in 2021 at "Magnetic resonance in medicine"
DOI: 10.1002/mrm.29025
Abstract: PURPOSE The number of glomeruli is different in men and women, as they also present different prevalence and progression of chronic kidney disease. A recent study has demonstrated a potential difference in renal metabolism between… read more here.
Keywords: metabolism; number; pyruvate metabolism; glomeruli pyruvate ... See more keywords
Abnormal early folliculogenesis due to impeded pyruvate metabolism in mouse oocytes†
Sign Up to like & getrecommendations! Published in 2021 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioab064
Abstract: Abstract Fetal ovarian germ cells show characteristic energy metabolism status, such as enhanced mitochondrial metabolism as well as glycolysis, but their roles in early folliculogenesis are unclear. We show here that inhibition of pyruvate uptake… read more here.
Keywords: folliculogenesis; early folliculogenesis; pyruvate metabolism; abnormal early ... See more keywords
The Role of Pyruvate Metabolism in Mitochondrial Quality Control and Inflammation
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DOI: 10.14348/molcells.2023.2128
Abstract: Pyruvate metabolism, a key pathway in glycolysis and oxidative phosphorylation, is crucial for energy homeostasis and mitochondrial quality control (MQC), including fusion/fission dynamics and mitophagy. Alterations in pyruvate flux and MQC are associated with reactive… read more here.
Keywords: mitochondrial quality; pyruvate metabolism; role; quality control ... See more keywords
Hyperpolarized 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma—A Proof of Principle Study
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DOI: 10.3390/cancers14020335
Abstract: Simple Summary We evaluated renal cancer with varying aggressive appearances on histology, using an emerging form of non-invasive metabolic MRI. This imaging technique assesses the uptake and metabolism of a breakdown product of glucose (pyruvate)… read more here.
Keywords: tumor; pyruvate metabolism; pyruvate; 13c pyruvate ... See more keywords