In silico studies and evaluation of antiparasitic role of a novel pyruvate phosphate dikinase inhibitor in Leishmania donovani infected macrophages.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2018.12.011
Abstract: The present work deals with the identification and characterization of a novel inhibitor Z220582104, specific to pyruvate phosphate dikinase, for leishmanicidal activities against free promastigotes and intracellular amastigotes. We have used structure-based drug designing approaches… read more here.
Keywords: inhibitor; phosphate dikinase; pyruvate phosphate; infected macrophages ... See more keywords
Small-molecule inhibition of pyruvate phosphate dikinase targeting the nucleotide binding site
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DOI: 10.1371/journal.pone.0181139
Abstract: Pyruvate phosphate dikinase (PPDK) is an essential enzyme of C4 photosynthesis in plants, catalyzing the ATP-driven conversion of pyruvate to phosphoenolpyruvate (PEP). It is further used by some bacteria and unicellular protists in the reverse,… read more here.
Keywords: pyruvate phosphate; phosphate dikinase; inhibition; pyruvate ... See more keywords