Analysis of the Amine Submetabolome Using Novel Isotope-Coded Pyrylium Salt Derivatization and LC-MS: Herbs and Cancer Tissues as Cases.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04246
Abstract: The amine submetabolome, including amino acids (AAs) and biogenic amines (BAs), is a class of small molecular compounds exhibiting important physiological activities. Here, a new pyrylium salt named 6,7-dimethoxy-3-methyl isochromenylium tetrafluoroborate ([d0]-DMMIC) with stable isotope-labeled… read more here.
Keywords: isotope; analysis; amine submetabolome; pyrylium salt ... See more keywords
Combined Transcriptome and Metabolome Analysis Reveals That the Potent Antifungal Pyrylium Salt Inhibits Mitochondrial Complex I in Candida albicans
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DOI: 10.1128/spectrum.03209-22
Abstract: The development of new antifungal drugs is critical for solving the problem of antifungal resistance and expanding the limited variety of clinical antifungal drugs. Based on the modification of the pyrylium salt SM21, a new… read more here.
Keywords: mitochondrial complex; antifungal drugs; xy12; pyrylium salt ... See more keywords
Design, Synthesis and Antifungal Evaluation of Novel Pyrylium Salt In Vitro and In Vivo
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DOI: 10.3390/molecules27144450
Abstract: Nowadays, discovering new skeleton antifungal drugs is the direct way to address clinical fungal infections. Pyrylium salt SM21 was screened from a library containing 50,240 small molecules. Several studies about the antifungal activity and mechanism… read more here.
Keywords: vitro vivo; antifungal activities; activity; pyrylium salt ... See more keywords