Distinct features of crude oils from Nyurol’ka Depression (Southeast of Western Siberia)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Petroleum Science and Engineering"
DOI: 10.1016/j.petrol.2017.04.017
Abstract: Abstract Aryl isoprenoids detected in Nyurol’ka Depression oils are unique biomarkers of photic zone anoxia (PZA) and they could be a key for the oil nature determination. In this study, the composition of the oils… read more here.
Keywords: depression; nyurol depression; aryl isoprenoids; oils nyurol ... See more keywords
Pyrazinamide resistance and pncA mutations in drug resistant Mycobacterium tuberculosis clinical isolates from Myanmar.
Sign Up to like & getrecommendations! Published in 2020 at "Tuberculosis"
DOI: 10.1016/j.tube.2020.102013
Abstract: Pyrazinamide (PZA) is an important anti-tuberculosis drug, which is active against semi-dormant bacilli and used as a component of first-line drugs and drug-resistant tuberculosis regimens. Mutations in pncA and its promoter region are main cause… read more here.
Keywords: drug resistant; tuberculosis; resistance; pza ... See more keywords
Structural insights of catalytic mechanism in mutant pyrazinamidase of Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1761879
Abstract: Abstract Pyrazinamidase (PZase) is a member of Fe-dependent amidohydrolases that activates pyrazinamide (PZA) into active pyrazinoic acid (POA). PZA, a nicotinamide analogue, is an essential first-line drug used in Mycobacterium tuberculosis (Mtb) treatment. The active… read more here.
Keywords: mechanism; tuberculosis; pza; pyrazinamidase ... See more keywords
Global status of phenotypic pyrazinamide resistance in Mycobacterium tuberculosis clinical isolates: an updated systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemotherapy"
DOI: 10.1080/1120009x.2023.2214473
Abstract: Pyrazinamide (PZA) is an essential first-line tuberculosis drug for its unique mechanism of action active against multidrug-resistant-TB (MDR-TB). Thus, the aim of updated meta-analysis was to estimate the PZA weighted pooled resistance (WPR) rate in… read more here.
Keywords: tuberculosis; resistance; meta analysis; pza ... See more keywords
Rapid and Sensitive LC-MS/MS Method for Simultaneous Determination of Three First-Line Oral Antituberculosis Drug in Plasma.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmaa130
Abstract: A bioanalytical method for simultaneous quantification of isoniazid (INH), pyrazinamide (PZA) and ethambutol (EMB) in plasma was developed and validated using high-performance liquid chromatography with tandem mass spectrometry. After extracted by protein precipitation with acetonitrile,… read more here.
Keywords: inh; plasma; method; method simultaneous ... See more keywords
Reply to Anthony et al., “Protecting Pyrazinamide, a Priority for Improving Outcomes in Multidrug-Resistant Tuberculosis Treatment”
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00427-17
Abstract: We thank Anthony and colleagues (1) for their interest in our work (2) and for emphasizing the potentially grave implications of pyrazinamide (PZA) resistance for the programmatic treatment of drug-resistant tuberculosis (TB). Indeed, as Anthony… read more here.
Keywords: treatment; drug; anthony; tuberculosis ... See more keywords
Detection of Pyrazinamide Heteroresistance in Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2021 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00720-21
Abstract: Heteroresistance is defined as the coexistence of both susceptible and resistant bacteria in a bacterial population. Previously published data show that it may occur in 9 to 57% of Mycobacterium tuberculosis isolates for various drugs.… read more here.
Keywords: pza; drug; mycobacterium tuberculosis; heteroresistance ... See more keywords
Population Pharmacokinetics of Pyrazinamide in Patients with Tuberculosis
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DOI: 10.1128/aac.02625-16
Abstract: ABSTRACT The current treatment used for tuberculosis (TB) is lengthy and needs to be shortened and improved. Pyrazinamide (PZA) has potent sterilizing activity and has the potential to shorten the TB treatment duration, if treatment… read more here.
Keywords: pyrazinamide patients; population pharmacokinetics; body weight; pza ... See more keywords
Introducing RpsA Point Mutations Δ438A and D123A into the Chromosome of Mycobacterium tuberculosis Confirms Their Role in Causing Resistance to Pyrazinamide
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02681-18
Abstract: Pyrazinamide (PZA) is a unique frontline drug for shortening tuberculosis (TB) treatment, but its mechanisms of action are elusive. We previously found one PZA-resistant strain that harbors an alanine deletion at position 438 (Δ438A) in… read more here.
Keywords: pza resistance; resistance; pza; tuberculosis ... See more keywords
Quantitative 1H Nuclear Magnetic Resonance Assay for the Rapid Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis from Sputum Samples
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.01522-22
Abstract: Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the 10 leading killer diseases in the world. At least one-quarter of the population has been infected, and there are 1.3 million deaths annually. ABSTRACT Tuberculosis… read more here.
Keywords: mycobacterium tuberculosis; nuclear magnetic; tuberculosis; sputum ... See more keywords
Ability of the MeltPro MTB/PZA Assay to Detect Susceptibility to Pyrazinamide in Rifampin-Resistant Tuberculosis Patients
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04836-22
Abstract: This study evaluated the accuracy of the MeltPro MTB/PZA assay at detecting the presence of PZA resistance through registered clinical trials. Compared to DNA sequencing, the assay had high sensitivity and negative predictive value, suggesting… read more here.
Keywords: tuberculosis; pza; pza assay; meltpro mtb ... See more keywords