Assessment of the potential therapeutic effects of omeprazole in Schistosoma mansoni infected mice
Sign Up to like & getrecommendations! Published in 2019 at "Parasitology Research"
DOI: 10.1007/s00436-019-06465-w
Abstract: Schistosomiasis is a neglected chronic parasitic disease with a significant lasting morbidity. Currently, praziquantel (PZQ) is the most efficient drug for schistosomiasis worldwide. However, the possibility of the occurrence of resistance to PZQ is increasing.… read more here.
Keywords: mansoni; effects omeprazole; therapeutic effects; potential therapeutic ... See more keywords
Evaluation of Praziquantel Effectivenss After Decades of Prolonged Use in an Endemic Area in Egypt
Sign Up to like & getrecommendations! Published in 2020 at "Acta Parasitologica"
DOI: 10.1007/s11686-020-00242-x
Abstract: Purpose Praziquantel (PZQ) is the preferred drug for schistomiasis treatment because of its safety. As PZQ is used for mass drug administration (MDA) in schistosomiasis endemic areas, the effectiveness of the drug, used solely for… read more here.
Keywords: endemic area; dose pzq; infection; drug ... See more keywords
In vivo praziquantel efficacy of Schistosoma japonicum over time: a systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Acta tropica"
DOI: 10.1016/j.actatropica.2021.106048
Abstract: Praziquantel (PZQ), the only choice of chemotherapy for schistosomiasis recommended by World Health Organization (WHO), has been widely used over 40 years. The long-term, and rapid expansion of, PZQ use for disease control across a… read more here.
Keywords: systematic review; time; efficacy; meta ... See more keywords
Absorption and depletion of dietary administered praziquantel in greater amberjack, Seriola dumerili
Sign Up to like & getrecommendations! Published in 2021 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2021.736354
Abstract: Abstract The absorption and depletion of dietary administered praziquantel (PZQ) were explored in greater amberjack, Seriola dumerili, a promising farmed fish species in the Mediterranean area and elsewhere. Greater amberjack weighing 84 g were fed once… read more here.
Keywords: greater amberjack; amberjack; pzq; praziquantel ... See more keywords
Co-administration of silymarin elevates the therapeutic effect of praziquantel through modulation of specific antibody profiles, Th1/Th2/Tregs cytokines and down-regulation of fibrogenesis in mice with Mesocestoides vogae (Cestoda) infection.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2020.107888
Abstract: Silymarin (SIL) represents a natural mixture of polyphenols showing an array of health benefits. The present study, carried out on a model cestode infection induced by Mesocestoides vogae tetrathyridia in the ICR strain of mice,… read more here.
Keywords: administration; effect; th1 th2; therapy ... See more keywords
The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02084-0
Abstract: Schistosomiasis is a debilitating tropical disease caused by infection with parasitic blood flukes. Approximately 260 million people are infected worldwide, underscoring the clinical and socioeconomic impact of this chronic infection. Schistosomiasis is treated with the… read more here.
Keywords: human serotoninergic; protein coupled; coupled receptor; praziquantel ... See more keywords
Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2217732120
Abstract: The drug praziquantel (PZQ) is the key clinical therapy for treating schistosomiasis and other infections caused by parasitic flatworms. A schistosome target for PZQ was recently identified- a transient receptor potential ion channel in the… read more here.
Keywords: parasitic flatworm; sensitivity; pzq; flatworm ... See more keywords
Repurposing anthelmintic praziquantel to treat psoriasis.
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DOI: 10.1111/bph.15652
Abstract: BACKGROUND AND PURPOSE The anthelmintic drug praziquantel (PZQ) has been used as a standard treatment for schistosomiasis for over 40 years. This study aimed to repurpose PZQ to treat psoriasis. EXPERIMENTAL APPROACH Psoriasis-like skin inflammation… read more here.
Keywords: stat3 phosphorylation; praziquantel; psoriasis; treat psoriasis ... See more keywords
Praziquantel Targets M1 Macrophages and Ameliorates Splenomegaly in Chronic Schistosomiasis
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DOI: 10.1128/aac.00005-17
Abstract: ABSTRACT Splenomegaly is a common feature of many infectious diseases, including schistosomiasis japonica. However, the immunopathogenesis and the treatment of splenomegaly due to schistosomiasis have been largely neglected. Praziquantel (PZQ), a classical schistosomicide, has been… read more here.
Keywords: schistosomiasis; praziquantel targets; number macrophages; number ... See more keywords
OC 8510 BIOTRANSFORMATION OF PRAZIQUANTEL FOR THE PHARMACOKINETIC OPTIMISATION OF PRAZIQUANTEL USE IN MASS DRUG ADMINISTRATION AND DEVELOPMENT OF NEW PAEDIATRIC FORMULATIONS
Sign Up to like & getrecommendations! Published in 2019 at "BMJ Global Health"
DOI: 10.1136/bmjgh-2019-edc.26
Abstract: Background Praziquantel (PZQ) is the only drug available for the treatment of all forms of schistosomiasis. New paediatric formulations for the active enantiomer R-PZQ and the racemate PZQ are currently under development. There is however… read more here.
Keywords: new paediatric; drug; pzq; praziquantel ... See more keywords
The mechanism of action of praziquantel: can new drugs exploit similar mechanisms?
Sign Up to like & getrecommendations! Published in 2018 at "Current medicinal chemistry"
DOI: 10.2174/0929867325666180926145537
Abstract: Praziquantel (PZQ) is the drug of choice for treating infection with worms from the genus Schistosoma. The drug is effective, cheap and has few side-effects. However, despite its use in millions of patients for over… read more here.
Keywords: mechanism; drug; drugs exploit; pzq ... See more keywords