Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx375
Abstract: Abstract Background Ciprofloxacin, a fluoroquinolone, targets two essential bacterial enzymes, DNA gyrase and topoisomerase IV. Plasmid-borne qnr genes, encoding proteins that protect DNA gyrase and topoisomerase IV from inhibition by fluoroquinolones, contribute to resistance development.… read more here.
Keywords: confer clinical; clinical resistance; ciprofloxacin; expression ... See more keywords
Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets
Sign Up to like & getrecommendations! Published in 2017 at "BMC Genomics"
DOI: 10.1186/s12864-017-4064-0
Abstract: BackgroundFluoroquinolones are broad-spectrum antibiotics used to prevent and treat a wide range of bacterial infections. Plasmid-mediated qnr genes provide resistance to fluoroquinolones in many bacterial species and are increasingly encountered in clinical settings. Over the… read more here.
Keywords: validation; qnr genes; gene; qnr ... See more keywords