Thorough QTc Evaluation and the Safety of Supratherapeutic Doses of Odanacatib in Healthy Subjects
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DOI: 10.1002/cpdd.698
Abstract: Assessing risk for QTc interval prolongation in a thorough QTc study is a standard recommendation when evaluating new chemical entities. As part of the clinical development program for odanacatib, an oral selective inhibitor of cathepsin… read more here.
Keywords: safety; qtc evaluation; study; thorough qtc ... See more keywords
Thorough QT/QTc Evaluation of the Cardiac Safety of Secnidazole at Therapeutic and Supratherapeutic Doses in Healthy Individuals
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DOI: 10.1002/jcph.1014
Abstract: SYM‐1219, a novel oral granule formulation of secnidazole, is under development as single‐dose treatment for bacterial vaginosis. This 4‐way, randomized, crossover study evaluated the effects of SYM‐1219 on electrocardiographic (ECG) parameters in 52 healthy subjects.… read more here.
Keywords: sym 1219; qtc evaluation; safety; evaluation cardiac ... See more keywords