Dynamic changes of QTc interval and prognostic significance in takotsubo (stress) cardiomyopathy
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DOI: 10.1002/clc.22798
Abstract: Prolonged QT corrected (QTc) intervals are associated with adverse cardiovascular outcomes both in healthy and high‐risk populations. Our objective was to evaluate the QTc intervals during a takotsubo cardiomyopathy (TTC) episodes and their potential prognostic… read more here.
Keywords: qtc interval; interval prognostic; significance takotsubo; dynamic changes ... See more keywords
Effect of Pevonedistat, an Investigational NEDD8‐Activating Enzyme Inhibitor, on the QTc Interval in Patients With Advanced Solid Tumors
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DOI: 10.1002/cpdd.1194
Abstract: The purpose of this study was to assess the effect of pevonedistat, a neural precursor cell expressed, developmentally down‐regulated protein 8 (NEDD8)‐activating enzyme inhibitor, on the heart rate‐corrected QT (QTc) interval in cancer patients. Patients… read more here.
Keywords: nedd8 activating; activating enzyme; effect pevonedistat; qtc ... See more keywords
Randomized, Blinded, Placebo‐ and Positive‐Controlled Crossover Study to Determine the Effect of Deferiprone on the QTc Interval in Healthy Subjects
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DOI: 10.1002/cpdd.352
Abstract: This study evaluated whether deferiprone, an oral iron chelator, acts to prolong the QT interval. Fifty healthy volunteers received single doses of each of the following: therapeutic dose of deferiprone (33 mg/kg), supratherapeutic dose (50… read more here.
Keywords: qtc interval; deferiprone; study; effect ... See more keywords
A Phase 1 Study of Intravenous Plazomicin in Healthy Adults to Assess Potential Effects on the QT/QTc Interval, Safety, and Pharmacokinetics
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DOI: 10.1002/cpdd.653
Abstract: Plazomicin is an aminoglycoside with in vitro activity against multidrug‐resistant Enterobacteriaceae. A phase 1, randomized, double‐blind, crossover study assessed the potential effects of plazomicin on cardiac repolarization (NCT01514929). Fifty‐six healthy adults (24 men, 32 women)… read more here.
Keywords: phase; healthy adults; qtc interval; effect ... See more keywords
Clinical Considerations of Isavuconazole Administration in High-Risk Hematological Patients: A Single-Center 5-Year Experience.
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DOI: 10.1007/s11046-021-00583-9
Abstract: BACKGROUND There are limited real-life data on isavuconazole prophylaxis and treatment of invasive mold infections (IMI) in hematological patients and allogeneic hematopoietic cell transplant (HCT) recipients. OBJECTIVES Primary objective was to describe the indications of… read more here.
Keywords: isavuconazole administration; hematological patients; range; qtc interval ... See more keywords
Prolongation of QTc interval at the beginning and during dialysis is associated with hypervolemia and calcium and magnesium change in the first 2 h
Sign Up to like & getrecommendations! Published in 2021 at "International Urology and Nephrology"
DOI: 10.1007/s11255-021-03016-0
Abstract: High rates of sudden cardiac death are mostly attributed to ventricular arrhythmias including QTc prolongation in hemodialysis patients. We aimed to investigate the correlation of electrolyte and volume changes with QTc interval prolongation in hemodialysis… read more here.
Keywords: qtc interval; group; interval beginning; dialysis ... See more keywords
A Randomized Trial to Assess the Effect of Doravirine on the QTc Interval Using a Single Supratherapeutic Dose in Healthy Adult Volunteers
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DOI: 10.1007/s40261-017-0552-x
Abstract: IntroductionDoravirine is a novel HIV-1 non-nucleoside reverse transcriptase inhibitor exhibiting a robust safety and efficacy profile in combination with other antiretrovirals. While existing data do not suggest that doravirine delays cardiac repolarization, the aim of… read more here.
Keywords: doravirine; qtc; trial; qtc interval ... See more keywords
Effects of Nemonoxacin on Thorough ECG QT/QTc Interval: A Randomized, Placebo- and Positive-controlled Crossover Study in Healthy Chinese Adults.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2018.04.014
Abstract: PURPOSE Nemonoxacin, a nonfluorinated quinolone, has been approved in Taiwan and mainland China for the treatment of bacterial infection. Whether nemonoxacin is associated with the adverse events of other quinolones, such as the risk for… read more here.
Keywords: qtc; qtc interval; effects nemonoxacin; study ... See more keywords
QTc Interval in psychiatric inpatients: A retrospective study
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DOI: 10.1016/j.eurpsy.2017.01.528
Abstract: Introduction Several psychotropic medications (i.e. antipsychotics, antidepressant) have been recently associated with QTc prolongation. Despite literature data report only mild prolongation of QTc following the use of antidepressants or typical antipsychotics, post-marketing studies have clearly… read more here.
Keywords: qtc; qtc prolongation; qtc interval; interval psychiatric ... See more keywords
Predictors of electrocardiographic screening failure for the subcutaneous implantable cardioverter-defibrillator in children: A prospective multicenter study.
Sign Up to like & getrecommendations! Published in 2018 at "Heart rhythm"
DOI: 10.1016/j.hrthm.2018.01.004
Abstract: BACKGROUND Subcutaneous implantable cardioverter-defibrillator (SICD) shows promise for select patients at risk of sudden cardiac death. However, patients need to pass an electrocardiographic (ECG) screening (ECG-S) test before they can receive an SICD. Predictors of… read more here.
Keywords: qtc interval; subcutaneous implantable; qrs duration; failure ... See more keywords
QTc interval prolongation in Systemic Sclerosis: Correlations with clinical variables and arrhythmic risk.
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DOI: 10.1016/j.ijcard.2017.03.088
Abstract: Article history: Received 13 March 2017 Accepted 16 March 2017 rhythmias, irrespective of QTc interval duration, as well as the potential life-saving role of an ICD-based approach in SSc patientswith cardiac involvement and a high… read more here.
Keywords: qtc; qtc interval; prolongation systemic; systemic sclerosis ... See more keywords