A powerful test for the maximum treatment effect in thorough QT/QTc studies.
Sign Up to like & getrecommendations! Published in 2021 at "Statistics in medicine"
DOI: 10.1002/sim.8881
Abstract: Parallel-group thorough QT/QTc studies focus on the change of QT/QTc values at several time-matched points from a pretreatment day (baseline) to a posttreatment day for different groups of treatment. The International Council for Harmonisation E14… read more here.
Keywords: qtc; qtc prolongation; qtc studies; treatment ... See more keywords
Development of a risk score for QTc-prolongation: the RISQ-PATH study
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Clinical Pharmacy"
DOI: 10.1007/s11096-017-0446-2
Abstract: AbstractBackground More than 170 drugs are linked with QTc-prolongation, which in extreme cases can lead to Torsade de Pointes. Monitoring of this potential side effect is an important challenge in clinical practice. Objective To investigate… read more here.
Keywords: score; risk; risq path; qtc prolongation ... See more keywords
2-1-102. Changes in corrected QT interval during electroconvulsive therapy
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2017.03.017
Abstract: Corrected QT interval (QTc) prolongation can trigger ventricular arrhythmia, including torsade de pointes (TdP). A QTc greater than 500 ms is considered to provide a high risk of TdP. Herein, we evaluated the risk of TdP… read more here.
Keywords: qtc prolongation; corrected interval; electroconvulsive therapy; prolongation ... See more keywords
QTc Interval in psychiatric inpatients: A retrospective study
Sign Up to like & getrecommendations! Published in 2017 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2017.01.528
Abstract: Introduction Several psychotropic medications (i.e. antipsychotics, antidepressant) have been recently associated with QTc prolongation. Despite literature data report only mild prolongation of QTc following the use of antidepressants or typical antipsychotics, post-marketing studies have clearly… read more here.
Keywords: qtc; qtc prolongation; qtc interval; interval psychiatric ... See more keywords
HCQ prophylaxis in COVID-19 did not show any QTc prolongation in Healthcare workers
Sign Up to like & getrecommendations! Published in 2020 at "Indian Heart Journal"
DOI: 10.1016/j.ihj.2020.11.005
Abstract: Background HCQ is a commonly recommended drug for the prophylaxis of COVID-19. One of its rare side-effect includes QTc prolongation. Methods This was a prospective, cross sectional and observational study conducted on Hydroxychloroquine (HCQ) among… read more here.
Keywords: qtc prolongation; hcq prophylaxis; healthcare workers; prophylaxis covid ... See more keywords
Which QTc correction formulae (Bazett, Framingham, or Fridericia) to use for Hydroxychloroquine induced QTc prolongation?
Sign Up to like & getrecommendations! Published in 2020 at "Indian Pacing and Electrophysiology Journal"
DOI: 10.1016/j.ipej.2020.06.008
Abstract: Which QTc correction formulae (Bazett, Framingham, or Fridericia) to use for Hydroxychloroquine induced QTc prolongation? World Health Organisation has declared COVID-19 as pandemic on March 11, 2020. Hydroxychloroquine has been recommended for treatment as well… read more here.
Keywords: induced qtc; hydroxychloroquine; qtc prolongation; bazett ... See more keywords
Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2020.106871
Abstract: INTRODUCTION The Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative differentiates torsadogenic risk of 28 drugs affecting ventricular repolarization based on multiple in vitro human derived ionic currents. However, a standardized prospective assessment of the electrophysiologic… read more here.
Keywords: qtc prolongation; torsadogenic risk; model; ten cipa ... See more keywords
Prevalence and Risk Factors of QTc Prolongation in Prostate Cancer Patients Undergoing Brachytherapy
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DOI: 10.1080/07357907.2022.2027435
Abstract: Abstract QTc prolongation is linked to Torsade de Pointes, sudden cardiac death, and overall cardiovascular mortality. 754 prostate cancer patients undergoing brachytherapy were analyzed, prolonged QTc was defined as ≥450ms. A prolonged QTc was more… read more here.
Keywords: prostate cancer; cancer patients; patients undergoing; qtc prolongation ... See more keywords
QT interval in patients receiving HCQ in SARS-CoV-2- A study on risk factors and correlation of baseline QTc with delta QTc in Pakistani population
Sign Up to like & getrecommendations! Published in 2021 at "Europace"
DOI: 10.1093/europace/euab116.017
Abstract: Abstract Funding Acknowledgements Type of funding sources: None. Introduction Hydroxychloroquine(HCQ) use alone or in combination with Azithromycin (AZM) in SARS-CoV-2 infection is associated with QTc prolongation and risk of arrhythmias. Objectives To determine changes in… read more here.
Keywords: qtc; combination; hcq; qtc prolongation ... See more keywords
Multicentre study of posaconazole delayed-release tablet serum level and association with hepatotoxicity and QTc prolongation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx122
Abstract: Objectives The association of posaconazole serum concentrations and toxicity is unclear. An assessment of whether levels obtained with the delayed-release tablet (DRT) formulation are correlated with abnormal liver function test (LFT) results and/or QTc prolongation… read more here.
Keywords: qtc prolongation; study; level; serum ... See more keywords
A Real-World Study of Risk Factors for QTc Prolongation in Schizophrenia Patients Receiving Atypical Antipsychotics
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Psychopharmacology"
DOI: 10.1097/jcp.0000000000001501
Abstract: Abstract Purpose The risk of sudden cardiac death in patients receiving atypical antipsychotics may be related to QTc prolongation. The aim of this study was to investigate the risk factors for QTc prolongation to prevent… read more here.
Keywords: prolongation; atypical antipsychotics; receiving atypical; qtc prolongation ... See more keywords