Reverse-QTY code design of active human serum albumin self-assembled amphiphilic nanoparticles for effective anti-tumor drug doxorubicin release in mice
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2220173120
Abstract: Significance QTY code has been successfully used to significantly improve the solubility of water-insoluble integral transmembrane proteins. They include G protein-coupled receptors, cytokine receptors, glucose transporters, and solute carrier transporters through systematically replacing the hydrophobic… read more here.
Keywords: qty; qty code; reverse qty; human serum ... See more keywords
Structural bioinformatics studies of serotonin, dopamine and norepinephrine transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1371/journal.pone.0300340
Abstract: Monoamine transporters including transporters for serotonin, dopamine, and norepinephrine play key roles in monoaminergic synaptic signaling, involving in the molecular etiology of a wide range of neurological and physiological disorders. Despite being crucial drug targets,… read more here.
Keywords: bioinformatics studies; serotonin dopamine; dopamine norepinephrine; qty ... See more keywords