Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03135c
Abstract: The single-stranded RNA genome of SARS-CoV-2 contains some G-quadruplex-forming G-rich elements which are putative drug targets. Here, we performed a ligand-based pharmacophore virtual screening of FDA approved drugs to find candidates targeting such RNA structures.… read more here.
Keywords: rna quadruplex; quadruplex binders; ligand based; cov rna ... See more keywords
G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab500
Abstract: Abstract G-quadruplexes (G4s) are non-canonical nucleic acid structures involved in fundamental biological processes. As G4s are promising anticancer targets, in past decades the search for effective anticancer G4 binders aimed at the discovery of more… read more here.
Keywords: quadruplex binders; binders cytostatic; cancer cells; cancer ... See more keywords
Metal-Based G-Quadruplex Binders for Cancer Theranostics
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14070605
Abstract: The ability of fluorescent small molecules, such as metal complexes, to selectively recognize G-quadruplex (G4) structures has opened a route to develop new probes for the visualization of these DNA structures in cells. The main… read more here.
Keywords: binders cancer; based quadruplex; quadruplex binders; metal based ... See more keywords