Selective C9orf72 G-Quadruplex-Binding Small Molecules Ameliorate Pathological Signatures of ALS/FTD Models
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DOI: 10.1021/acs.jmedchem.2c00654
Abstract: The G-quadruplex (G4) forming C9orf72 GGGGCC (G4C2) expanded hexanucleotide repeat (EHR) is the predominant genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Developing selective G4-binding ligands is challenging due to the conformational… read more here.
Keywords: quadruplex binding; binding small; c9orf72; g4c2 ... See more keywords
Synthesis, G-quadruplex binding properties and cytotoxicity of naphthalimide–thiourea conjugates
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DOI: 10.1039/c7nj02366a
Abstract: Four novel naphthalimide–thiourea conjugates 3a–d have been prepared and characterized. The interactions of these compounds with duplex and telomeric G-quadruplex DNA have been investigated by UV-Vis spectroscopy, fluorescence spectroscopy, viscosity and cyclic voltammetric measurements. The… read more here.
Keywords: naphthalimide thiourea; thiourea conjugates; dna; spectroscopy ... See more keywords
G-Quadruplex-Binding Proteins: Promising Targets for Drug Design
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DOI: 10.3390/biom12050648
Abstract: G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with the potential to form G4s are abundant in regulatory regions of the genome including telomeres, promoters and 5′ non-coding regions, indicating they fulfill important genome… read more here.
Keywords: quadruplex binding; promising targets; targets drug; binding proteins ... See more keywords
Synthesis and Investigation of the G-Quadruplex Binding Properties of Kynurenic Acid Derivatives with a Dihydroimidazoquinoline-3,5-dione Core
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DOI: 10.3390/molecules27092791
Abstract: G-quadruplexes are secondary structures originating from nucleic acid regions rich in guanines, which are well known for their involvement in gene transcription and regulation and DNA damage repair. In recent studies from our group, kynurenic… read more here.
Keywords: quadruplex binding; kynurenic acid; quadruplex; investigation quadruplex ... See more keywords