Tracing Effects of Fluorine Substitutions on G-Quadruplex Conformational Changes.
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DOI: 10.1021/acschembio.6b01096
Abstract: A human telomere sequence that folds into an intramolecular (3 + 1)-hybrid G-quadruplex was modified by the incorporation of 2'-fluoro-2'-deoxyriboguanosines (FG) into syn positions of its outer tetrad. A circular dichroism and NMR spectral analysis… read more here.
Keywords: substitutions quadruplex; tracing effects; fluorine substitutions; quadruplex conformational ... See more keywords