Refining our methodologies for assessing quadruplex DNA ligands; selectivity or an illusion of selectivity?
Sign Up to like & getrecommendations! Published in 2020 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2020.113744
Abstract: Regulation of transcription and replication by the tetrad patterns of DNA has drawn the attention of many scientists. In this note, we discuss some disparaged parameters in the study of G-quadruplex structures (G4-tetrads). Besides, the… read more here.
Keywords: refining methodologies; quadruplex dna; dna ligands; ligands selectivity ... See more keywords
Structural and biophysical insight into dual site binding of the protoberberine alkaloid palmatine to parallel G-quadruplex DNA using NMR, fluorescence and Circular Dichroism spectroscopy.
Sign Up to like & getrecommendations! Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2018.02.002
Abstract: Plant derived small molecules, which interact with and stabilize G-quadruplex DNA, act as inhibitors of telomere elongation and oncogene expression in humans. The inhibition of telomerase enzyme has immense potential since it is over expressed… read more here.
Keywords: dna; quadruplex dna; nmr fluorescence; spectroscopy ... See more keywords
Synthesis of fluorescent G-quadruplex DNA binding ligands for the comparison of terminal group effects in molecular interaction: Phenol versus methoxybenzene.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103821
Abstract: A number of new fluorescent nucleic acid binding ligands were synthesized by utilizing the non-specific thiazole orange dye as the basic scaffold for molecular design. Under simple synthetic conditions, the molecular scaffold of thiazole orange… read more here.
Keywords: binding ligands; dna; quadruplex dna; group ... See more keywords
Selective stabilization of multiple promoter G-quadruplex DNA by using 2-phenyl-1H-imidazole-based tanshinone IIA derivatives and their potential suppressing function in the metastatic breast cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104433
Abstract: The G-quadruplex (G4) DNA, which has been developed as a potential anticancer target in drug screening and design, plays a crucial role in the oncogene transcription and translation. Tanshinone IIA derivatives with a planar heterocycle… read more here.
Keywords: iia derivatives; quadruplex dna; tanshinone iia;
Specific stabilization of promoter G-Quadruplex DNA by 2,6-disubstituted amidoanthracene-9,10-dione based dimeric distamycin analogues and their selective cancer cell cytotoxicity.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112202
Abstract: We have designed and synthesized anthraquinone containing compounds which have oligopyrrole side chains of varying lengths. These compounds stabilized the G-quadruplex DNA formed in the promoter regions of c-MYC oncogenes selectively over the duplex DNA.… read more here.
Keywords: cytotoxicity; dna; quadruplex dna; cancer cell ... See more keywords
Binding of anticancer drug daunomycin to parallel G-quadruplex DNA [d-(TTGGGGT)]4 leads to thermal stabilization: A multispectroscopic investigation.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.09.154
Abstract: Guanine rich DNA sequences form four stranded G-quadruplex structures found in telomeric DNA and oncogene promoters. Small molecules binding and stabilizing the G-quadruplex disrupt telomere maintenance and gene regulation, thereby limiting the proliferation of cancer… read more here.
Keywords: thermal stabilization; daunomycin; dna; quadruplex dna ... See more keywords
Spectroscopic and molecular docking studies for the binding and interaction aspects of curcumin-cysteine conjugate and rosmarinic acid with human telomeric G-quadruplex DNA.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.05.089
Abstract: The binding and interaction aspects of potential anticancer ligands like: curcumin-cysteine (CC) and rosmarinic acid (RA) with human telomeric G-quadruplex DNA, a novel anticancer target, have been probed by spectroscopic and molecular docking approach. The… read more here.
Keywords: quadruplex dna; human telomeric; spectroscopic molecular; telomeric quadruplex ... See more keywords
Arylsulfanyl groups - Suitable side chains for 5-substituted 1,10-phenanthroline and nickel complexes as G4 ligands and telomerase inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2017.04.018
Abstract: Guanine-rich DNA sequences can undergo self-assembly into unique G-quadruplex structures that interfere with the binding of proteins to the same DNA region. The formation of DNA G-quadruplexes requires monovalent cations (Na+ and K+) or small… read more here.
Keywords: side chains; arylsulfanyl groups; dna; quadruplex dna ... See more keywords
Investigation of Binding behaviour of a water-soluble gallium(III) phthalocyanine with double-stranded and G-quadruplex DNA via experimental and computational methods
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130536
Abstract: Abstract DNA is an important target for the development of chemotherapeutic drug design due to increased and uncontrolled cell proliferation of cancer cells. In the present study, the affinity of water-soluble gallium(III) phthalocyanine chloride (GaPc)… read more here.
Keywords: soluble gallium; dna; double stranded; quadruplex dna ... See more keywords
Determination of a structural ensemble representing the dynamics of a G-quadruplex DNA.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00493
Abstract: It is increasingly recognised that the structure and dynamics of G-quadruplex DNA are dictated by its sequence and greatly affected by environmental factors. The core guanine tetrads (G-tetrads) coordinate cations and display a strong conformational… read more here.
Keywords: dna; quadruplex dna; determination structural; structural ensemble ... See more keywords
Dimeric Metal-Salphen Complexes Which Target Multimeric G-Quadruplex DNA
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate Chemistry"
DOI: 10.1021/acs.bioconjchem.3c00114
Abstract: G-Quadruplex DNA structures have attracted increasing attention due to their biological roles and potential as targets for the development of new drugs. While most guanine-rich sequences in the genome have the potential to form monomeric… read more here.
Keywords: quadruplex dna; chemistry; dimeric metal; metal salphen ... See more keywords