Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection.
Sign Up to like & getrecommendations! Published in 2021 at "Biochimie"
DOI: 10.1016/j.biochi.2021.03.017
Abstract: G-quadruplexes contribute to the regulation of key molecular processes. Their utilization for antiviral therapy is an emerging field of contemporary research. Here we present comprehensive analyses of the presence and localization of putative G-quadruplex forming… read more here.
Keywords: infection; analyses viral; type; viral genomes ... See more keywords
Controlling liquid-liquid phase separation of G-quadruplex-forming RNAs in a sequence-specific manner.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc04366a
Abstract: We constructed a minimum liquid-liquid phase separation model system to form liquid droplets using only G-quadruplex-forming oligonucleotides and R- and G-rich oligopeptides. We found that the G-quadruplex structure is an essential component for RNA to… read more here.
Keywords: specific manner; liquid phase; quadruplex forming; phase separation ... See more keywords
Endogenous G-quadruplex-forming RNAs inhibit the activity of SARS-CoV-2 RNA polymerase.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc05858h
Abstract: Replication of RNA viruses is catalysed by virus-specific polymerases, which can be targets of therapeutic strategies. In this study, we used a selection strategy to identify endogenous RNAs from a transcriptome library derived from lung… read more here.
Keywords: quadruplex forming; rna polymerase; activity; endogenous quadruplex ... See more keywords
RNA G-quadruplex forming regions from SARS-2, SARS-1 and MERS coronoviruses
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.1014663
Abstract: COVID-19 (Corona Virus Disease 2019), SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) are infectious diseases each caused by coronavirus outbreaks. Small molecules and other therapeutics are rapidly being developed to treat… read more here.
Keywords: forming regions; regions sars; rna quadruplex; quadruplex forming ... See more keywords
Quadruplex-Forming Motif Inserted into 3′UTR of Ty1his3-AI Retrotransposon Inhibits Retrotransposition in Yeast
Sign Up to like & getrecommendations! Published in 2021 at "Biology"
DOI: 10.3390/biology10040347
Abstract: Simple Summary Four-stranded DNA (guanine quadruplex) can regulate many cellular processes such as replication, recombination and also gene expression. This study shows that four-stranded DNA can also affect the activity of mobile genetic elements (transposable… read more here.
Keywords: motif; forming motif; ty1his3; retrotransposition ... See more keywords
Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22073433
Abstract: The importance of gene expression regulation in viruses based upon G-quadruplex may point to its potential utilization in therapeutic targeting. Here, we present analyses as to the occurrence of putative G-quadruplex-forming sequences (PQS) in all… read more here.
Keywords: pqs; host; virus host; quadruplex forming ... See more keywords
Detection of CpG Methylation in G-Quadruplex Forming Sequences Using G-Quadruplex Ligands
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222313159
Abstract: Genomic DNA methylation is involved in many diseases and is expected to be a specific biomarker for even the pre-symptomatic diagnosis of many diseases. Thus, a rapid and inexpensive detection method is required for disease… read more here.
Keywords: cpg methylation; methylation; methylation quadruplex; detection ... See more keywords
Analysis of G-Quadruplex-Forming Sequences in Drought Stress-Responsive Genes, and Synthesis Genes of Phenolic Compounds in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13010199
Abstract: Sequences of nucleic acids with the potential to form four-stranded G-quadruplex structures are intensively studied mainly in the context of human diseases, pathogens, or extremophile organisms; nonetheless, the knowledge about their occurrence and putative role… read more here.
Keywords: quadruplex forming; responsive genes; stress responsive; drought stress ... See more keywords
Exploring the Interaction of G-quadruplex Binders with a (3 + 1) Hybrid G-quadruplex Forming Sequence within the PARP1 Gene Promoter Region
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154792
Abstract: The enzyme PARP1 is an attractive target for cancer therapy, as it is involved in DNA repair processes. Several PARP1 inhibitors have been approved for clinical treatments. However, the rapid outbreak of resistance is seriously… read more here.
Keywords: promoter; within parp1; quadruplex forming; sequence ... See more keywords
Stabilization of the Quadruplex-Forming G-Rich Sequences in the Rhinovirus Genome Inhibits Uncoating—Role of Na+ and K+
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15041003
Abstract: Rhinoviruses (RVs) are the major cause of common cold, a respiratory disease that generally takes a mild course. However, occasionally, RV infection can lead to serious complications in patients debilitated by other ailments, e.g., asthma.… read more here.
Keywords: stabilization quadruplex; quadruplex forming; stabilization; rna ... See more keywords