Chromatin Immunoprecipitation Assay to Analyze the Effect of G-Quadruplex Interactive Agents on the Binding of RNA Polymerase II and Transcription Factors to a Target Promoter Region.
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DOI: 10.1007/978-1-4939-9666-7_13
Abstract: Growing evidence suggests the existence of G-quadruplexes and their involvement in transcriptional regulation of many human genes, including VEGF. These studies also provide strong evidence that G-quadruplex structures are stabilized by binding to small molecules,… read more here.
Keywords: promoter region; transcription; interactive agents; quadruplex interactive ... See more keywords
NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds.
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DOI: 10.1007/978-1-4939-9666-7_9
Abstract: G-quadruplexes are noncanonical, four-stranded nucleic acid secondary structures formed in sequences containing consecutive runs of guanines. These G-quadruplex structures have been found to form in nucleic acid regions of biological significance, including human telomeres, gene… read more here.
Keywords: nmr studies; interactive compounds; studies quadruplex; quadruplex structures ... See more keywords