Binding and Beyond: What Else Can G-Quadruplex Ligands Do?
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201900692
Abstract: G-quadruplexes (G4) are four-stranded structures formed from guanine-rich oligonucleotides. Their defined 3D structures and polymorphic nature set them apart from classical nucleic acid morphology and suggest a range of potential applications in the development of… read more here.
Keywords: binding beyond; biology; beyond else; topology ... See more keywords
G‐quadruplex ligands inhibit chikungunya virus replication
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27622
Abstract: Chikungunya virus (CHIKV) is a mosquito‐transmitted alphavirus affecting human health globally. G‐quadruplex secondary structures attract great attention as potential targets for antiviral strategy. In this study, we show that the CHIKV genome possesses several conserved… read more here.
Keywords: quadruplex sequences; chikungunya virus; replication; quadruplex ligands ... See more keywords
Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00772
Abstract: G-quadruplex (G4) ligands are investigated to discover new anticancer drugs with increased cell-killing potency. These ligands can induce genome instability and activate innate immune genes at non-cytotoxic doses, opening the discovery of cytostatic immune-stimulating ligands.… read more here.
Keywords: cytotoxicity; selectivity cytotoxicity; quadruplex ligands; affinity selectivity ... See more keywords
Manipulating adult neural stem and progenitor cells with G-quadruplex ligands.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00194
Abstract: G-quadruplexes are pervasive nucleic acid secondary structures in mammalian genomes and transcriptomes that regulate gene expression and genome duplication. Small molecule ligands that modify the stability of G-quadruplexes are widely studied in cancer, but whether… read more here.
Keywords: adult neural; quadruplex ligands; progenitor cells; neural stem ... See more keywords
G-quadruplex ligands as potent regulators of lysosomes.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2170071
Abstract: Guanine-quadruplex structures (G4) are unusual nucleic acid conformations formed by guanine-rich DNA and RNA sequences and known to control gene expression mechanisms, from transcription to protein synthesis. So far, a number of molecules that recognize… read more here.
Keywords: quadruplex ligands; potent regulators; regulation; ligands potent ... See more keywords
Characterization of G-Quadruplexes in Enterovirus A71 Genome and Their Interaction with G-Quadruplex Ligands
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00460-22
Abstract: G-quadruplex is a stable nucleic acid secondary structure formed by the folding of guanine rich nucleic acid. The important regulatory function of G-quadruplex makes it an attractive target of antiviral effect. ABSTRACT Human enteroviruses cause… read more here.
Keywords: a71 genome; human enteroviruses; quadruplex ligands; nucleic acid ... See more keywords