Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment.
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DOI: 10.1021/acs.jmedchem.6b01563
Abstract: G-quadruplex stabilizers are an established opportunity in anticancer chemotherapy. To circumvent the antiproliferative effects of G4 ligands, cancer cells recruit PARP enzymes at telomeres. Herein, starting from the structural similarity of a potent G4 ligand… read more here.
Keywords: dual quadruplex; discovery dual; stabilizers poly; quadruplex stabilizers ... See more keywords