Putting a New Spin of G-Quadruplex Structure and Binding by Analytical Ultracentrifugation.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9666-7_5
Abstract: Analytical ultracentrifugation is a powerful biophysical tool that provides information about G-quadruplex structure, stability, and binding reactivity. This chapter provides a simplified explanation of the method, along with examples of how it can be used… read more here.
Keywords: analytical ultracentrifugation; quadruplex structure; putting new; new spin ... See more keywords
In Silico Screening and Binding Characterization of Small Molecules toward a G-Quadruplex Structure Formed in the Promoter Region of c-MYC Oncogene
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DOI: 10.1021/acsomega.6b00531
Abstract: Overexpression of c-MYC oncogene is associated with cancer pathology. Expression of c-MYC is regulated by the G-quadruplex structure formed in the G-rich segment of nuclease hypersensitive element (NHE III1), that is, “Pu27”, which is localized… read more here.
Keywords: myc oncogene; promoter region; structure formed; quadruplex structure ... See more keywords
Structural insight for the recognition of G-quadruplex structure at human c-myc promoter sequence by flavonoid Quercetin
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03906-3
Abstract: Small molecule ligands that could stabilize G-quadruplex structure formed at the promoter region of human c-myc oncogene will regulate its expression in cancer cells. Flavonoids, a group of naturally available small molecule, have been known… read more here.
Keywords: quadruplex structure; myc promoter; structure; human myc ... See more keywords
A G-quadruplex structure at the 5′ end of the H19 coding region regulates H19 transcription
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DOI: 10.1038/srep45815
Abstract: The H19 gene, one of the best known imprinted genes, encodes a long non-coding RNA that regulates cell proliferation and differentiation. H19 RNA is widely expressed in embryonic tissues, but its expression is restricted in… read more here.
Keywords: transcription; quadruplex structure; expression; h19 gene ... See more keywords
Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5'-UTR.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00070g
Abstract: G quadruplex structures have been predicted by bioinformatics to form in the 5'- and 3'-untranslated regions (UTRs) of several thousand mature mRNAs and are believed to play a role in translation regulation. Elucidation of these… read more here.
Keywords: protein; structure within; quadruplex structure; survival motor ... See more keywords
A chair-type G-quadruplex structure formed by a human telomeric variant DNA in K+ solution† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03813a
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c8sc03813a
Abstract: The chair-type G-quadruplex structure formed by human telomeric variant DNA. read more here.
Keywords: chair type; human telomeric; quadruplex structure; structure formed ... See more keywords
G-quadruplex structure of the C. elegans telomeric repeat: a two tetrads basket type conformation stabilized by a non-canonical C–T base-pair
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac523
Abstract: Abstract The Caenorhabditis elegans model has greatly contributed to the understanding of the role of G-quadruplexes in genomic instability. The GGCTTA repeats of the C. elegans telomeres resemble the GGGTTA repeats of the human telomeres.… read more here.
Keywords: basket type; structure; two tetrads; elegans telomeric ... See more keywords
Encoding canonical DNA quadruplex structure
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DOI: 10.1126/sciadv.aat3007
Abstract: The remarkable architectural diversity of four-stranded DNA known as G-quadruplexes can be rationally designed. The main challenge in DNA quadruplex design is to encode a three-dimensional structure into the primary sequence, despite its multiple, repetitive… read more here.
Keywords: encoding canonical; quadruplex structure; dna quadruplex; dna ... See more keywords