In Cell NMR Spectroscopy: Investigation of G-Quadruplex Structures Inside Living Xenopus laevis Oocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9666-7_25
Abstract: G-quadruplexes are inherently polymorphic nucleic acid structures. Their folding topology depends on the nucleic acid primary sequence and on physical-chemical environmental factors. Hence, it remains unclear if a G-quadruplex topology determined in the test tube… read more here.
Keywords: xenopus laevis; laevis oocytes; topology; quadruplex structures ... See more keywords
19F NMR Spectroscopy for the Analysis of DNA G-Quadruplex Structures Using 19F-Labeled Nucleobase.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9666-7_26
Abstract: G-quadruplex structures have been suggested to be biologically important in processes such as transcription and translation, gene expression and regulation in human cancer cells, and regulation of telomere length. Investigation of G-quadruplex structures associated with… read more here.
Keywords: spectroscopy analysis; nmr spectroscopy; quadruplex structures; spectroscopy ... See more keywords
NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9666-7_9
Abstract: G-quadruplexes are noncanonical, four-stranded nucleic acid secondary structures formed in sequences containing consecutive runs of guanines. These G-quadruplex structures have been found to form in nucleic acid regions of biological significance, including human telomeres, gene… read more here.
Keywords: nmr studies; interactive compounds; studies quadruplex; quadruplex structures ... See more keywords
A practical guide to studying G-quadruplex structures using single-molecule FRET
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-017-1288-2
Abstract: In this article, we summarize the knowledge and best practices learned from bulk and single-molecule measurements to address some of the frequently experienced difficulties in single-molecule Förster resonance energy transfer (smFRET) measurements on G-quadruplex (GQ)… read more here.
Keywords: molecule; single molecule; quadruplex structures; practical guide ... See more keywords
G-quadruplex structures formed by human telomeric DNA and C9orf72 hexanucleotide repeats
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical Reviews"
DOI: 10.1007/s12551-019-00545-y
Abstract: DNA or RNA strands that are composed stretches of guanines (G-tracts) divided by other bases are able to form Gquadruplexes, a tetra-helical structure with stacked G-tetrad planes connected by Hoogsteen hydrogen bonds and stabilized by… read more here.
Keywords: structures formed; human telomeric; dna; telomeric dna ... See more keywords
Development of a multitasking fluorescent probe for differentiating G-Quadruplex structures
Sign Up to like & getrecommendations! Published in 2019 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2019.107560
Abstract: Abstract G-quadruplexes exhibit extensive structural polymorphism, which are highly related to their biological functions. To date, multitasking probes that can simultaneously discriminate among parallel, antiparallel G-quadruplexes and single-/double-stranded nucleic acids have never been reported. In… read more here.
Keywords: quadruplex structures; fluorescent probe; antiparallel quadruplexes; probe differentiating ... See more keywords
Borderline Boolean states improve the biosensing applications of DNA circuits.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.03.197
Abstract: Molecular circuits have been used in a wide range of diagnosis applications, from the detection of chemical molecules in solution to the complex processing of cell surface receptors. One of the most important challenges of… read more here.
Keywords: boolean states; quadruplex structures; biosensing applications; states improve ... See more keywords
The SNAIL1 promoter contains G-quadruplex structures regulating its gene expression and DNA replication.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112158
Abstract: SNAIL1 is a key regulator of epithelial-mesenchymal transition (EMT) and its expression is associated with tumor progression and poor clinical prognosis of cancer patients. Compared to the studies of SNAIL1 stability and its transcriptional regulation,… read more here.
Keywords: snail1 promoter; snail1; quadruplex structures; gene expression ... See more keywords
Targeting Parallel Topology of G-Quadruplex Structures by Indole- Fused Quindoline Scaffolds.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00373
Abstract: Preferential stabilization of G-quadruplex (G4) structures using small-molecule ligands has emerged as an effective approach to develop anticancer drugs. Herein, we report the synthesis of three indole-fused quindoline derivatives with varying lengths of side chains… read more here.
Keywords: topology; indole fused; fused quindoline; targeting parallel ... See more keywords
Biophysical Characterization of Nucleolin Domains Crucial for Interaction with Telomeric and TERRA G-Quadruplexes.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00641
Abstract: Nucleolin (NCL) is a well-characterized nucleic acid-binding protein; it binds to various canonical and noncanonical structures including single- and double-stranded DNA and RNA, hairpin, loops, and G-quadruplex structures. G-quadruplex structures are majorly formed in promoter,… read more here.
Keywords: characterization nucleolin; biophysical characterization; rna; nucleolin ... See more keywords
G-Quadruplex Structures as a "Switch" Regulate ATF4 Expression in Ferroptotic HepG2 Cells.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00615
Abstract: G-quadruplex (G4) is a noncanonical structure folded in a widespread manner by guanine-rich tandem repeated sequences. As a key response factor, activating transcription factor 4 (ATF4) has dual functions in managing iron-dependent ferroptosis by regulating… read more here.
Keywords: atf4 expression; quadruplex structures; expression; structures switch ... See more keywords