Hydroxyl groups in cosolutes regulate the G-quadruplex topology of telomeric DNA.
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DOI: 10.1016/j.bbrc.2020.02.045
Abstract: Telomeric G-quadruplex topology has the ability to regulate telomerase activity, which counteracts the shortening of telomere with successive cell divisions, thereby causing genomic longevity. However, the detailed mechanism of G-quadruplexes topologies formed by telomeric sequences… read more here.
Keywords: hydroxyl groups; topology; quadruplex topology; telomeric dna ... See more keywords