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Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7816-8_16
Abstract: A characteristic feature of transmissible spongiform encephalopathies (TSE) is the progressive accumulation of protein aggregates in the brain in a self-propagation manner. Based on this mechanism, in vitro protein amplification systems (such as real-time quaking-induced…
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Keywords:
protein;
real time;
prion;
quaking induced ... See more keywords
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2
Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.898516
Abstract: The real-time quaking-induced conversion (RT-QuIC) assay has been developed and used as an in vitro diagnostic tool for Parkinson’s disease (PD). In this study, we established α-Syn RT-QuIC using recombinant human α-Syn as the substrate.…
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Keywords:
time quaking;
quic;
quaking induced;
brain ... See more keywords
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1
Published in 2018 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2018.3867
Abstract: In order to definitively diagnosis sporadic Creutzfeldt-Jakob disease (sCJD), brain tissue is currently required. Therefore, there is a great need for tests that can detect sCJD in body fluids or other types of tissues. Different…
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Keywords:
real time;
quaking induced;
induced conversion;
prpsc detection ... See more keywords