Quantitative NMR-Based Metabolomics on Tissue Biomarkers and Its Translation into In Vivo Magnetic Resonance Spectroscopy.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9236-2_23
Abstract: Nuclear magnetic resonance (NMR) spectroscopy is an established analytical platform for analyzing metabolic profiles of cells, tissues, and body fluids. There are several advantages in introducing an NMR-based study design into metabolomics studies, including a… read more here.
Keywords: quantitative nmr; nmr; magnetic resonance; spectroscopy ... See more keywords
Fast Quantitative 2D NMR for Untargeted and Targeted Metabolomics.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9690-2_20
Abstract: Nuclear magnetic resonance (NMR) spectroscopy exhibits a great potential for the quantitative analysis of complex biological samples such as those encountered in metabolomics. To overcome the ubiquitous problem of overlapping peaks in 1D NMR spectra… read more here.
Keywords: quantitative nmr; nmr; nmr untargeted; targeted metabolomics ... See more keywords
Establishment of an analytical method for accurate purity evaluations of acylcarnitines by using quantitative 1H NMR spectroscopy
Sign Up to like & getrecommendations! Published in 2017 at "Accreditation and Quality Assurance"
DOI: 10.1007/s00769-017-1263-y
Abstract: Recently, it has become possible to examine metabolism abnormalities by detecting increases in specific acylcarnitines in blood tests of newborn babies using tandem mass spectrometer. However, acylcarnitine standard solutions with metrological traceability to the International… read more here.
Keywords: quantitative nmr; temperature; purity evaluations; spectroscopy ... See more keywords
Comparison of various commercially available cinnamon barks using NMR metabolomics and the quantification of coumarin by quantitative NMR methods.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of natural medicines"
DOI: 10.1007/s11418-021-01554-6
Abstract: Cinnamon bark is an important spice worldwide. In this study, the chemical diversity of various commercially available cinnamon barks that differed in their production areas and utility applications (culinary spice or medicines) were investigated by… read more here.
Keywords: quantitative nmr; available cinnamon; cinnamon barks; commercially available ... See more keywords
NMR-based isotopic and isotopomic analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Progress in nuclear magnetic resonance spectroscopy"
DOI: 10.1016/j.pnmrs.2020.07.001
Abstract: Molecules exist in different isotopic compositions and most of the processes, physical or chemical, in living systems cause selection between heavy and light isotopes. Thus, knowing the isotopic fractionation of the common atoms, such as… read more here.
Keywords: quantitative nmr; isotope; spectroscopy; based isotopic ... See more keywords
Tautomerization and Isomerization in Quantitative NMR: A Case Study with 4-Deoxynivalenol (DON).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c08053
Abstract: The regulated mycotoxin 4-deoxynivalenol (DON) has a heterocyclic structure that is readily amenable to tautomerization and conformational isomerization in solution. An analysis of DON in solution by NMR revealed the presence of hemiacetal tautomer(s) and… read more here.
Keywords: isomerization; quantitative nmr; tautomerization isomerization; tautomerization ... See more keywords
Quantitative NMR (qNMR) spectroscopy based investigation of the absolute content, stability and isomerization of 25-hydroxyvitamin D2/D3 and 24(R),25-dihydroxyvitamin D2 in solution phase
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-06948-4
Abstract: Vitamin D is an important parameter, in serum/plasma based diagnostic analysis, for the determination of optimal regulation of calcium and phosphate homeostases in the human body, vital for the monitoring/progression of osteomalacia and rickets. Particularly,… read more here.
Keywords: spectroscopy; quantitative nmr; hydroxyvitamin; absolute content ... See more keywords
Quantitative NMR spectroscopy of complex mixtures.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01455j
Abstract: Complex mixtures are ubiquitous in many branches of chemistry, be it a complex pharmaceutical formulation, a collection of biofluids analysed in a metabolomics workflow, or a flowing mixture in a reaction monitoring setting. The accurate… read more here.
Keywords: complex mixtures; spectroscopy; quantitative nmr; spectroscopy complex ... See more keywords
Quantitative NMR analysis of the kinetics of prenucleation oligomerization and aggregation of pathogenic huntingtin exon-1 protein
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207690119
Abstract: Significance Huntington’s disease is a fatal neurodegenerative condition caused by polyglutamine expansion (≥35) in the N-terminal region of the huntingtin protein encoded by exon-1 (httex1), resulting in fibril accumulation within neuronal inclusion bodies. Microsecond-timescale reversible… read more here.
Keywords: oligomerization; nmr analysis; quantitative nmr; huntingtin ... See more keywords
Quantitative NMR Interpretation without Reference
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Analytical Methods in Chemistry"
DOI: 10.1155/2022/7490691
Abstract: As has been documented numerous times over the years, nuclear magnetic resonance (NMR) experiments are intrinsically quantitative. Still, quantitative NMR methods have not been widely adopted or largely introduced into pharmacopoeias. Here, we describe the… read more here.
Keywords: quantitative nmr; interpretation; without reference; interpretation without ... See more keywords
Quantitative NMR-Based Lipoprotein Analysis Identifies Elevated HDL-4 and Triglycerides in the Serum of Alzheimer’s Disease Patients
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012472
Abstract: Alzheimer’s disease (AD) is the most common form of dementia in the elderly and has been associated with changes in lipoprotein metabolism. We performed quantitative lipoprotein analysis in a local cohort of cognitively impaired elderly… read more here.
Keywords: nmr based; alzheimer disease; quantitative nmr; lipoprotein analysis ... See more keywords