Rapid and Quantitative Profiling of Substrate Specificity of ω‐Transaminases for Ketones
Sign Up to like & getrecommendations! Published in 2019 at "ChemCatChem"
DOI: 10.1002/cctc.201900399
Abstract: ω‐Transaminases (ω‐TAs) have gained growing attention owing to their capability for asymmetric synthesis of chiral amines from ketones. Reliable high‐throughput activity assay of ω‐TAs is essential in carrying out extensive substrate profiling and establishing a… read more here.
Keywords: profiling; quantitative profiling; profiling substrate; substrate profiling ... See more keywords
Quantitative Profiling of Lysosomal Lipidome by Shotgun Lipidomics.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6934-0_2
Abstract: Recent studies have illuminated novel roles of lysosomes that go far beyond simple catabolism and function in the coordination of cellular metabolism and signaling. Promising therapeutic strategies emerge from knowledge in the molecular mechanisms and… read more here.
Keywords: quantitative profiling; profiling lysosomal; metabolism; shotgun lipidomics ... See more keywords
Isoprostanoids quantitative profiling of marine red and brown macroalgae.
Sign Up to like & getrecommendations! Published in 2018 at "Food chemistry"
DOI: 10.1016/j.foodchem.2018.06.111
Abstract: With the increasing demand for direct human and animal consumption seaweed farming is rapidly expanding worldwide. Macroalgae have colonized aquatic environments in which they are submitted to frequent changes in biotic and abiotic factors that… read more here.
Keywords: quantitative profiling; macroalgae; profiling marine; brown macroalgae ... See more keywords
ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12653
Abstract: The quantitative profiling of residue reactivity in proteins promotes the discovery of covalent druggable targets for precise therapy. Histidine (His) residues, accounting for more than 20% of the active sites in enzymes, have not been… read more here.
Keywords: human proteome; quantitative profiling; reactivity; histidine ... See more keywords
Quantitative profiling of CD13 on single acute myeloid leukemia cells by super-resolution imaging and its implication in targeted drug susceptibility assessment.
Sign Up to like & getrecommendations! Published in 2019 at "Nanoscale"
DOI: 10.1039/c8nr06526h
Abstract: Quantitative profiling of membrane proteins on the cell surface is of great interest in tumor targeted therapy and single cell biology. However, the existing technologies are either of insufficient resolution, or unable to provide precise… read more here.
Keywords: quantitative profiling; resolution; microscopy; cell surface ... See more keywords
Quantitative profiling of selective Sox/POU pairing on hundreds of sequences in parallel by Coop-seq
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw1198
Abstract: Cooperative binding of transcription factors is known to be important in the regulation of gene expression programs conferring cellular identities. However, current methods to measure cooperativity parameters have been laborious and therefore limited to studying… read more here.
Keywords: quantitative profiling; coop seq; half site; sox pou ... See more keywords
Quantitative profiling of endocannabinoids and related N-acylethanolamines in human CSF using nano LC-MS/MS[S]
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Lipid Research"
DOI: 10.1194/jlr.d070433
Abstract: Endocannabinoids, a class of lipid messengers, have emerged as crucial regulators of synaptic communication in the CNS. Dysregulation of these compounds has been implicated in many brain disorders. Although some studies have identified and quantified… read more here.
Keywords: endocannabinoids related; quantitative profiling; human csf; profiling endocannabinoids ... See more keywords
Quantitative Profiling of Oxylipins in Acute Experimental Intracerebral Hemorrhage
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2020.00777
Abstract: Oxylipins are a series of bioactive lipid metabolites derived from polyunsaturated fatty acids that are involved in cerebral homeostasis and the development of intracerebral hemorrhage (ICH). However, comprehensive quantification of the oxylipin profile in ICH… read more here.
Keywords: quantitative profiling; intracerebral hemorrhage; oxylipins ich; hemorrhage ... See more keywords