Quantitative single‐molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα‐induced NF‐ĸB signaling
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2ab0420-572rr
Abstract: TNFR1 is a crucial regulator of NF‐ĸB‐mediated proinflammatory cell survival responses and programmed cell death (PCD). Deregulation of TNFα‐ and TNFR1‐controlled NF‐ĸB signaling underlies major diseases, like cancer, inflammation, and autoimmune diseases. Therefore, although being… read more here.
Keywords: single molecule; quantitative single; tnf; tnf induced ... See more keywords
Quantitative Single-Residue Bioorthogonal Labeling of G Protein-Coupled Receptors in Live Cells.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b01115
Abstract: High-end microscopy studies of G protein-coupled receptors (GPCRs) require installing onto the receptors bright and photostable dyes. Labeling must occur in quantitative yields, to allow stoichiometric data analysis, and in a minimally invasive fashion, to… read more here.
Keywords: single residue; microscopy; labeling; protein coupled ... See more keywords
Quantitative single-molecule study reveals site-specific photo-oxidation activities and kinetics on 2D g-C3N4.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00750b
Abstract: We report the utilization of single-molecule fluorescence microscopy to in situ quantify the photo-oxidation reaction kinetics on g-C3N4. The wrinkle structure shows the highest reactivity and direct dissociation rate. The basal plane exhibits the highest… read more here.
Keywords: single molecule; kinetics c3n4; photo oxidation; quantitative single ... See more keywords
Quantitative single-molecule study of TGF-&bgr;/Smad signaling
Sign Up to like & getrecommendations! Published in 2018 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.1093/abbs/gmx121
Abstract: TGF-β/Smad signaling pathway triggers diverse cellular responses among different cell types and environmental conditions. Quantitative analysis of protein-protein interactions involved in TGF-β/Smad signaling is demanded for understanding the molecular mechanism of this signaling pathway. Live-cell… read more here.
Keywords: quantitative single; smad signaling; single molecule; tgf smad ... See more keywords
Quantitative single molecule analysis of podoplanin clustering in fibroblastic reticular cells uncovers CD44 function
Sign Up to like & getrecommendations! Published in 2023 at "Open Biology"
DOI: 10.1098/rsob.220377
Abstract: Upon initial immune challenge, dendritic cells (DCs) migrate to lymph nodes and interact with fibroblastic reticular cells (FRCs) via C-type lectin-like receptor 2 (CLEC-2). CLEC-2 binds to the membrane glycoprotein podoplanin (PDPN) on FRCs, inhibiting… read more here.
Keywords: single molecule; reticular cells; fibroblastic reticular; quantitative single ... See more keywords
Using quantitative single molecule localization microscopy to optimize multivalent HER2-targeting ligands
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1064242
Abstract: Introduction The progression-free survival of patients with HER2-positive metastatic breast cancer is significantly extended by a combination of two monoclonal antibodies, trastuzumab and pertuzumab, which target independent epitopes of the extracellular domain of HER2. The… read more here.
Keywords: single molecule; her2; combination; microscopy ... See more keywords