Quantitative spatial analysis of crystallin proteins in human lens epithelial cells
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-17896-0
Abstract: Resolving spatial protein dynamics in native human epithelial tissues presents a significant technical challenge, particularly in inherently curved or unevenly mounted specimens. Here, we introduce an image processing pipeline for high-resolution, compartment-based analysis of protein… read more here.
Keywords: crystallin; analysis; protein; quantitative spatial ... See more keywords
Quantitative spatial analysis of chromatin biomolecular condensates using cryoelectron tomography
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2426449122
Abstract: Significance Biomolecular condensates play important roles in cellular organization and function, but their internal structures remain poorly understood due to limitations in imaging techniques. This is true for both cellular condensates and those reconstituted biochemically.… read more here.
Keywords: chromatin; biomolecular condensates; analysis chromatin; quantitative spatial ... See more keywords
BIOM-27. PREDICTIVE EVALUATION OF QUANTITATIVE SPATIAL PROFILING OF THE TUMOR MICROENVIRONMENT BY MULTIPLEX IMMUNOFLUORESCENCE IN RECURRENT GLIOBLASTOMA TREATED WITH PD-1 INHIBITORS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.027
Abstract: PD-1 inhibitors have shown limited efficacy in glioblastoma (GBM) due to microenvironment immunosuppression and low tumor mutational burden. In GBM, PD-L1 expression is not a predictive marker for response to PD-1 or PD-L1 inhibitors. Multiplex… read more here.
Keywords: quantitative spatial; glioblastoma; multiplex immunofluorescence; tumor microenvironment ... See more keywords
Quantitative Spatial Profiling of Immune Populations in Pancreatic Ductal Adenocarcinoma Reveals Tumor Microenvironment Heterogeneity and Prognostic Biomarkers
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/0008-5472.can-22-1190
Abstract: Quantitative image analysis of PDAC specimens reveals intertumoral and intratumoral heterogeneity of immune populations and identifies spatial immune architectures that are significantly associated with disease prognosis. read more here.
Keywords: populations pancreatic; heterogeneity; immune populations; quantitative spatial ... See more keywords
Compact or spread? A quantitative spatial model of urban areas in Europe since 1990
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DOI: 10.1371/journal.pone.0192326
Abstract: Changes in urban residential density represent an important issue in terms of land consumption, the conservation of ecosystems, air quality and related human health problems, as well as the consequential challenges for urban and regional… read more here.
Keywords: compact spread; urban areas; model urban; quantitative spatial ... See more keywords
Quantitative Spatial Characterization of Lymph Node Tumor for N Stage Improvement of Nasopharyngeal Carcinoma Patients
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DOI: 10.3390/cancers15010230
Abstract: Simple Summary The N staging system for Nasopharyngeal Carcinoma (NPC) is constantly improving for better survival risk stratification with accumulating clinical evidence. Discovering new prognostic factors often depends on clinical observations, which often lack comprehensiveness… read more here.
Keywords: nasopharyngeal carcinoma; quantitative spatial; stage; risk ... See more keywords