The Systems Biology of Drug Metabolizing Enzymes and Transporters: Relevance to Quantitative Systems Pharmacology
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1818
Abstract: Quantitative systems pharmacology (QSP) has emerged as a transformative science in drug discovery and development. It is now time to fully rethink the biological functions of drug metabolizing enzymes (DMEs) and transporters within the framework… read more here.
Keywords: drug; pharmacology; physiology; biology ... See more keywords
Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutical Research"
DOI: 10.1007/s11095-019-2582-y
Abstract: PurposeMacrolide antibiotics are commonly prescribed treatments for drug-resistant bacterial infections; however, many macrolides have been shown to cause liver enzyme elevations and one macrolide, telithromycin, has been pulled from the market by its provider due… read more here.
Keywords: induced liver; toxicity; liver injury; quantitative systems ... See more keywords
A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability
Sign Up to like & getrecommendations! Published in 2022 at "Bulletin of Mathematical Biology"
DOI: 10.1007/s11538-021-00982-5
Abstract: There is an inherent tension in Quantitative Systems Pharmacology (QSP) between the need to incorporate mathematical descriptions of complex physiology and drug targets with the necessity of developing robust, predictive and well-constrained models. In addition… read more here.
Keywords: identifiability; parameter identifiability; pharmacology; systems pharmacology ... See more keywords
Better prediction of the local concentration-effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the evolution of model-informed drug discovery and development.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.05.016
Abstract: Model-informed drug discovery and development (MID3) is an umbrella term under which sit several computational approaches: quantitative systems pharmacology (QSP), quantitative systems toxicology (QST) and physiologically based pharmacokinetics (PBPK). QSP models are built using mechanistic… read more here.
Keywords: drug discovery; pharmacology; toxicology; quantitative systems ... See more keywords
Improving the generation and selection of virtual populations in quantitative systems pharmacology models.
Sign Up to like & getrecommendations! Published in 2018 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2018.06.002
Abstract: Quantitative systems pharmacology (QSP) models aim to describe mechanistically the pathophysiology of disease and predict the effects of therapies on that disease. For most drug development applications, it is important to predict not only the… read more here.
Keywords: qsp models; systems pharmacology; pharmacology; improving generation ... See more keywords
Quantitative Systems Toxicology Modeling To Address Key Safety Questions in Drug Development: A Focus of the TransQST Consortium.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00499
Abstract: Omics data have been increasingly generated with limited demonstrated value in drug safety assessment. The TransQST consortium was launched to use omics and other data in mechanistic-based quantitative systems toxicology (QST) models to evaluate their… read more here.
Keywords: safety; drug; transqst consortium; systems toxicology ... See more keywords
Receptor occupancy assessment and interpretation in terms of quantitative systems pharmacology: nivolumab case study
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2156317
Abstract: ABSTRACT Receptor occupancy assays applied in clinical studies provide insights into pharmacokinetic-pharmacodynamic relationships for therapeutic antibodies. When measured by different assays, however, receptor occupancy results can be controversial, as was observed for nivolumab, a monoclonal… read more here.
Keywords: systems pharmacology; pharmacology; quantitative systems; receptor occupancy ... See more keywords
A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice
Sign Up to like & getrecommendations! Published in 2018 at "BMC Systems Biology"
DOI: 10.1186/s12918-018-0603-9
Abstract: BackgroundThe yeast-like fungi Pneumocystis, resides in lung alveoli and can cause a lethal infection known as Pneumocystis pneumonia (PCP) in hosts with impaired immune systems. Current therapies for PCP, such as trimethoprim-sulfamethoxazole (TMP-SMX), suffer from… read more here.
Keywords: pneumocystis; treatment; pharmacology; quantitative systems ... See more keywords
A Review of Quantitative Systems Pharmacology Models of the Coagulation Cascade: Opportunities for Improved Usability
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15030918
Abstract: Despite the numerous therapeutic options to treat bleeding or thrombosis, a comprehensive quantitative mechanistic understanding of the effects of these and potential novel therapies is lacking. Recently, the quality of quantitative systems pharmacology (QSP) models… read more here.
Keywords: coagulation; systems pharmacology; pharmacology; quantitative systems ... See more keywords