Rapid and Quantitative In Vitro Evaluation of SARS-CoV-2 Neutralizing Antibodies and Nanobodies.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00062
Abstract: Neutralizing monoclonal antibodies and nanobodies have shown promising results as potential therapeutic agents for COVID-19. Identifying such antibodies and nanobodies requires evaluating the neutralization activity of a large number of lead molecules via biological assays,… read more here.
Keywords: evaluation sars; sars cov; quantitative vitro; vitro evaluation ... See more keywords
Quantitative In Vitro-to-In Vivo Extrapolation: Nominal versus Freely Dissolved Concentration.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00037
Abstract: Discussions are ongoing on which dose metric should be used for quantitative in vitro-to-in vivo extrapolation (QIVIVE) of in vitro bioassay data. The nominal concentration of the test chemicals is most commonly used and easily… read more here.
Keywords: vitro vivo; effect; freely dissolved; quantitative vitro ... See more keywords
Quantitative in Vitro to in Vivo Extrapolation (QIVIVE) for Predicting Reduced Anogenital Distance Produced by Anti-Androgenic Pesticides in a Rodent Model for Male Reproductive Disorders
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Health Perspectives"
DOI: 10.1289/ehp6774
Abstract: Background: Many pesticides can antagonize the androgen receptor (AR) or inhibit androgen synthesis in vitro but their potential to cause reproductive toxicity related to disruption of androgen action during fetal life is difficult to predict.… read more here.
Keywords: vitro vivo; vivo; model; quantitative vitro ... See more keywords