Regio- and Stereoselective Alkenylation of Allenoates with gem-Difluoroalkenes: Facile Access to Fluorinated 1,4-Enynes Bearing an All-Carbon Quaternary Center.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00775
Abstract: A regio- and stereoselective synthesis of fluorinated 1,4-enynes bearing an all-carbon quaternary center at the propargylic position is developed. The synthesis starts from readily available allenoates and gem-difluoroalkenes and proceeds via a key alkynylenolate intermediate… read more here.
Keywords: enynes bearing; carbon quaternary; fluorinated enynes; regio stereoselective ... See more keywords
Dearomatization of naphthols using oxy-allyl cations: efficient construction of α-all-carbon quaternary center-containing 2-(2-oxocycloalkyl)cycloalkyl diketones
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DOI: 10.1039/c8qo00783g
Abstract: A novel strategy for the dearomatization of naphthols using in situ generated oxy-allyl cations is reported. Both α- and β-naphthols can work well in this process. Using this catalyst-free methodology, various structurally diverse α-quaternary center-containing… read more here.
Keywords: dearomatization naphthols; naphthols using; allyl cations; oxy allyl ... See more keywords
Nucleotide Analogues Bearing a C2′ or C3′-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors
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DOI: 10.3390/molecules27020564
Abstract: The design of novel nucleoside triphosphate (NTP) analogues bearing an all-carbon quaternary center at C2′ or C3′ is described. The construction of this all-carbon stereogenic center involves the use of an intramoleculer photoredox-catalyzed reaction. The… read more here.
Keywords: carbon; quaternary center; analogues bearing; carbon quaternary ... See more keywords