Selective Formation of Functionalized α-Quaternary Malononitriles toward 5,5-Disubstituted Pyrrolopyrimidinones.
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DOI: 10.1021/acs.orglett.7b01930
Abstract: A modular, selective approach to complex α-tertiary substituted malononitriles is reported. The method takes advantage of β-ester-substituted α,α-dinitrile alkenes as highly reactive, chemoselective electrophiles for 1,4-additions with organometallic nucleophiles to produce functionally and sterically dense… read more here.
Keywords: malononitriles toward; functionalized quaternary; quaternary malononitriles; formation functionalized ... See more keywords