On the quaternary structure of human D‐3‐phosphoglycerate dehydrogenase
Sign Up to like & getrecommendations! Published in 2024 at "Protein Science"
DOI: 10.1002/pro.5089
Abstract: D‐3‐phosphoglycerate dehydrogenase (PHGDH) catalyzes the NAD+‐dependent conversion of D‐3‐phospho‐glycerate to 3‐phosphohydroxypyruvate, the first step in the phosphorylated pathway for L‐serine (L‐Ser) biosynthesis. L‐Ser plays different relevant metabolic roles in eukaryotic cells: alterations in L‐Ser metabolism… read more here.
Keywords: structure human; phosphoglycerate dehydrogenase; dehydrogenase; quaternary structure ... See more keywords
Reviewing the Crystal Structure of S100Z and Other Members of the S100 Family: Implications in Calcium-Regulated Quaternary Structure.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9030-6_30
Abstract: This paper takes the cue from the previously solved crystal structure of human apo-S100Z and compares it with that of the calcium-bound S100Z from zebrafish in order to stress, for this particular S100, the significant… read more here.
Keywords: quaternary structure; crystal structure; family; structure ... See more keywords
Intramembranal disulfide cross-linking elucidates the super-quaternary structure of mammalian CatSpers.
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive biology"
DOI: 10.1016/j.repbio.2018.01.005
Abstract: CatSper is a voltage-dependent calcium channel located in the plasma membrane of the sperm flagellum and is responsible for triggering hyperactive motility. A homology model for the transmembrane region was built in which the arrangement… read more here.
Keywords: quaternary structure; cross linking; structure; intramembranal disulfide ... See more keywords
Conformational Frustration at the Protein-Glycan Interface of a Nonmitogenic Anti-HIV Lectin Results in Altered Quaternary Structure.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical biology"
DOI: 10.1021/acschembio.5c00347
Abstract: Lectins are carbohydrate-binding proteins that have enormous therapeutic value because of their potent antiviral activity. However, the design of lectins for targeted intervention is marred by our poor understanding of protein-glycan recognition. Here, we focus… read more here.
Keywords: conformational frustration; quaternary structure; protein glycan; glycan interface ... See more keywords
An Assessment of Quaternary Structure Functionality in Homomer Protein Complexes
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad070
Abstract: Abstract It has been recently suggested that a significant fraction of homomer protein–protein interfaces evolve neutrally, without contributing to function, due to a hydrophobic bias in missense mutations. However, the fraction of such gratuitous complexes… read more here.
Keywords: structure; homomer protein; quaternary structure; fraction ... See more keywords
OR26-6 Glucocorticoid Receptor Quaternary Structure Drives Chromatin Occupancy and Transcriptional Outcome
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-or26-6
Abstract: Abstract The multimeric structure adopted by transcription factor complexes at their genomic sites of interaction is a longstanding problem in transcription biology. Information bearing on this question is often inferred from indirect data sources. Most… read more here.
Keywords: quaternary structure; receptor; glucocorticoid receptor; transcriptional outcome ... See more keywords
Evolution of interface binding strengths in simplified model of protein quaternary structure
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1006886
Abstract: The self-assembly of proteins into protein quaternary structures is of fundamental importance to many biological processes, and protein misassembly is responsible for a wide range of proteopathic diseases. In recent years, abstract lattice models of… read more here.
Keywords: quaternary structure; evolution; evolution interface; model ... See more keywords
Quaternary structure is an essential component that contributes to the sophisticated allosteric regulation mechanism in a key enzyme from Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0180052
Abstract: The first enzyme of the shikimate pathway, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS), adopts a range of distinct allosteric regulation mechanisms in different organisms, related to different quaternary assemblies. DAH7PS from Mycobacterium tuberculosis (MtuDAH7PS) is a homotetramer,… read more here.
Keywords: quaternary structure; allosteric regulation; amino acid; mycobacterium tuberculosis ... See more keywords
Investigating the quaternary structure of a homomultimeric catechol 1,2-dioxygenase: An integrative structural biology study
Sign Up to like & getrecommendations! Published in 2024 at "PLOS One"
DOI: 10.1371/journal.pone.0315992
Abstract: The structural analysis of catechol 1,2 dioxygenase from Stutzerimonas frequens GOM2, SfC12DO, was conducted using various structural techniques. SEC-SAXS experiments revealed that SfC12DO, after lyophilization and reconstitution processes, can form multiple enzymatically active oligomers, including… read more here.
Keywords: quaternary structure; investigating quaternary; biology; catechol dioxygenase ... See more keywords
Tertiary and Quaternary Structure Organization in GMP Synthetases: Implications for Catalysis
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12070871
Abstract: Glutamine amidotransferases, enzymes that transfer nitrogen from Gln to various cellular metabolites, are modular, with the amidotransferase (GATase) domain hydrolyzing Gln, generating ammonia and the acceptor domain catalyzing the addition of nitrogen onto its cognate… read more here.
Keywords: catalysis; structure; domain; quaternary structure ... See more keywords