Biosynthesis of bioactive tamarixetin in recombinant Escherichia coli
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DOI: 10.1002/bab.1958
Abstract: Tamarixetin, a monomethylated derivative of quercetin, has been reported to possess many important biological activities. In the present study, a whole cell biotransformation system was used for regiospecific methylation of quercetin to produce 4′‐O‐methylated quercetin… read more here.
Keywords: escherichia coli; methylated quercetin; tamarixetin; quercetin ... See more keywords
Quercetin shows anti‐tumor effect in hepatocellular carcinoma LM3 cells by abrogating JAK2/STAT3 signaling pathway
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DOI: 10.1002/cam4.2388
Abstract: Hepatocellular carcinima is one of the most common tumors in clinic and also one of the leading causes of death from cancer worldwide. Quercetin shows significant effects on blocking the development of various cancers. read more here.
Keywords: effect hepatocellular; shows anti; anti tumor; quercetin ... See more keywords
Quercetin plays protective role in oxidative induced apoptotic events during chronic chlorpyrifos exposure to rats
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DOI: 10.1002/jbt.22341
Abstract: Chlorpyrifos (CPF), an organophosphate insecticide has a wider application throughout the world to protect agricultural crops and vegetables from insects. Polyphenolic compounds are considered as beneficial against toxicities induced by organophosphates. The present study was… read more here.
Keywords: chlorpyrifos; caspase; apoptotic events; quercetin ... See more keywords
Quercetin administration post-weaning attenuates high-fructose, high-cholesterol diet-induced hepatic steatosis in growing, female, Sprague Dawley rat pups.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.9984
Abstract: BACKGROUND Fructose and cholesterol-rich diets are implicated in the upsurge of metabolic syndrome (MetS). Phytochemicals are being explored as alternatives for the prevention and management of MetS. Thirty-six, 21-day old, female, Sprague Dawley rats fed… read more here.
Keywords: diet induced; group; cholesterol; quercetin ... See more keywords
Quercetin reduced the formation of N‐acetyl‐p‐benzoquinoneimine, a toxic metabolite of paracetamol in rats and isolated rat hepatocytes
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DOI: 10.1002/ptr.6365
Abstract: N‐acetyl‐p‐benzoquinoneimine (NAPQI) is toxic metabolite of paracetamol formed primarily by cytochrome P4502E1 (CYP2E1) metabolic pathway when administered at therapeutic doses or overdose. The influence of quercetin (flavonoid) on the bioactivation of paracetamol to NAPQI was… read more here.
Keywords: acetyl benzoquinoneimine; formation; paracetamol; quercetin ... See more keywords
Dietary quercetin supplements: Assessment of online product informations and quantitation of quercetin in the products by high‐performance liquid chromatography
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DOI: 10.1002/ptr.6382
Abstract: Administration of the increasingly popular dietary supplements containing quercetin may interfere with drug therapy. We intended to evaluate the online availability and quercetin content of the high‐dose mono‐component quercetin products and to review the potential… read more here.
Keywords: dietary supplements; product; quercetin content; quercetin ... See more keywords
Quercetin protects against cisplatin‐induced acute kidney injury by inhibiting Mincle/Syk/NF‐κB signaling maintained macrophage inflammation
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DOI: 10.1002/ptr.6507
Abstract: Acute kidney injury (AKI) with high incidence and mortality is the main cause of chronic kidney disease. Previous studies have indicated that quercetin, an abundant flavonoid in plants, exhibited renoprotective role in AKI. However, the… read more here.
Keywords: mincle syk; macrophage inflammation; quercetin; mincle ... See more keywords
Quercetin and its role in modulating endoplasmic reticulum stress: A review
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DOI: 10.1002/ptr.7283
Abstract: The endoplasmic reticulum (ER) is the place where proteins and lipids are biosynthesized and where transmembrane proteins are folded. Both pathological and physiological situations may disturb the function of the ER, resulting in ER stress.… read more here.
Keywords: review; quercetin; stress; role ... See more keywords
A critical evaluation of risk to reward ratio of quercetin supplementation for COVID‐19 and associated comorbid conditions
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DOI: 10.1002/ptr.7461
Abstract: The interim results of the large, multinational trials on coronavirus disease 2019 (COVID‐19) using a combination of antiviral drugs appear to have little to no effect on the 28‐day mortality or the in‐hospital course. Therefore,… read more here.
Keywords: comorbid conditions; disease; covid; evaluation risk ... See more keywords
Quercetin inhibits the amphiregulin/EGFR signaling‐mediated renal tubular epithelial‐mesenchymal transition and renal fibrosis in obstructive nephropathy
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DOI: 10.1002/ptr.7599
Abstract: Quercetin is a widely distributed, bioactive flavonoid compound, which displays potential to inhibit fibrosis in several diseases. The purpose of our study was to determine the effect of quercetin treatment on renal fibrosis and investigate… read more here.
Keywords: renal fibrosis; quercetin inhibits; egfr signaling; tubular epithelial ... See more keywords
Quercetin for the treatment of COVID‐19 patients: A systematic review and meta‐analysis
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DOI: 10.1002/rmv.2427
Abstract: Currently approved therapies for COVID‐19 are mostly limited by their low availability, high costs or the requirement of parenteral administration by trained medical personnel in an in‐hospital setting. Quercetin is a cheap and easily accessible… read more here.
Keywords: covid patients; meta analysis; quercetin; systematic review ... See more keywords