Ten quick tips for getting the most scientific value out of numerical data
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DOI: 10.1371/journal.pcbi.1006141
Abstract: Most studies in the life sciences and other disciplines involve generating and analyzing numerical data of some type as the foundation for scientific findings. Working with numerical data involves multiple challenges. These include reproducible data… read more here.
Keywords: numerical data; scientific value; quick tips; getting scientific ... See more keywords
Ten quick tips for homology modeling of high-resolution protein 3D structures
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DOI: 10.1371/journal.pcbi.1007449
Abstract: Author summary The purpose of this quick guide is to help new modelers who have little or no background in comparative modeling yet are keen to produce high-resolution protein 3D structures for their study by… read more here.
Keywords: high resolution; protein structures; resolution protein; homology modeling ... See more keywords
Twelve quick tips for software design
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DOI: 10.1371/journal.pcbi.1009809
Abstract: Most people can lift one kilogram, but would struggle to lift one hundred, and could not lift a thousand without planning and support. Similarly, many researchers who can write a few lines of Python, R,… read more here.
Keywords: tips software; software; twelve quick; software design ... See more keywords
Nine quick tips for pathway enrichment analysis
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DOI: 10.1371/journal.pcbi.1010348
Abstract: Pathway enrichment analysis (PEA) is a computational biology method that identifies biological functions that are overrepresented in a group of genes more than would be expected by chance and ranks these functions by relevance. The… read more here.
Keywords: quick tips; enrichment analysis; nine quick; pathway enrichment ... See more keywords
Ten quick tips for computational analysis of medical images
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DOI: 10.1371/journal.pcbi.1010778
Abstract: Medical imaging is a great asset for modern medicine, since it allows physicians to spatially interrogate a disease site, resulting in precise intervention for diagnosis and treatment, and to observe particular aspect of patients’ conditions… read more here.
Keywords: analysis medical; ten quick; quick tips; medical images ... See more keywords
Ten quick tips for ensuring machine learning model validity
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DOI: 10.1371/journal.pcbi.1012402
Abstract: Author summary Artificial Intelligence (AI) and Machine Learning (ML) models are increasingly deployed on biomedical and health data to shed insights on biological mechanism, predict disease outcomes, and support clinical decision-making. However, ensuring model validity… read more here.
Keywords: quick tips; model validity; machine learning;
Eight quick tips for biologically and medically informed machine learning
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DOI: 10.1371/journal.pcbi.1012711
Abstract: Machine learning has become a powerful tool for computational analysis in the biomedical sciences, with its effectiveness significantly enhanced by integrating domain-specific knowledge. This integration has give rise to informed machine learning, in contrast to… read more here.
Keywords: quick tips; machine; machine learning; tips biologically ... See more keywords
Ten quick tips for protecting health data using de-identification and perturbation of structured datasets
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DOI: 10.1371/journal.pcbi.1013507
Abstract: Structured patient data generated within the health data ecosystem are shared both internally for operational use and also externally for research and public health benefit. Protecting individual privacy and health data confidentiality in these contexts… read more here.
Keywords: quick tips; tips protecting; identification; ten quick ... See more keywords