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   Articles with "quinacrine" as a keyword



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Protective effect of quinacrine against glycerol-induced acute kidney injury in rats

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recommendations! Published in 2017 at "BMC Nephrology"

DOI: 10.1186/s12882-017-0450-8

Abstract: BackgroundAcute kidney injury (AKI) is a serious clinical problem with high rate of mortality and morbidity. Currently used prophylactic and therapeutic strategies to address AKI are limited and warrant further studies. In the present study… read more here.

Keywords: glycerol induced; kidney injury; quinacrine; glycerol ... See more keywords

Quinacrine Has Preferential Anticancer Effects on Mesothelioma Cells With Inactivating NF2 Mutations

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recommendations! Published in 2021 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2021.750352

Abstract: Mesothelioma is a rare cancer with disproportionately higher death rates for shipping and mining populations. These patients have few treatment options, which can be partially attributed to limited chemotherapy responses for tumors. We initially hypothesized… read more here.

Keywords: nf2 mutations; mesothelioma cells; preferential anticancer; inactivating nf2 ... See more keywords
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Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy

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recommendations! Published in 2022 at "Molecules"

DOI: 10.3390/molecules27175561

Abstract: Topo II and Hsp90 are promising targets. In this study, we first verified the structural similarities between Topo IIα ATPase and Hsp90α N−ATPase. Subsequently, 720 compounds from the Food and Drug Administration (FDA) drug library… read more here.

Keywords: hsp90; topo hsp90; target inhibitor; dual target ... See more keywords
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Quinacrine pretreatment reduces microwave-induced neuronal damage by stabilizing the cell membrane

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recommendations! Published in 2018 at "Neural Regeneration Research"

DOI: 10.4103/1673-5374.228727

Abstract: Quinacrine, widely used to treat parasitic diseases, binds to cell membranes. We previously found that quinacrine pretreatment reduced microwave radiation damage in rat hippocampal neurons, but the molecular mechanism remains poorly understood. Considering the thermal… read more here.

Keywords: quinacrine pretreatment; cell membrane; quinacrine; damage ... See more keywords